dihydroouabain
dihydroouabain structure
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Common Name | dihydroouabain | ||
|---|---|---|---|---|
| CAS Number | 1183-35-3 | Molecular Weight | 586.66800 | |
| Density | 1.49 g/cm3 | Boiling Point | 827.7ºC at 760 mmHg | |
| Molecular Formula | C29H46O12 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 268.5ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Sodium-potassium-ATPase electrogenicity in cerebral precapillary arterioles.
Am. J. Physiol. Heart Circ. Physiol. 279(1) , H351-60, (2000) Electrogenicity of the Na(+)/K(+) pump has the capability to generate a large negative membrane potential independently of ion-channel current. The high background membrane resistance of arterioles may make them susceptible to such an effect. Pump current was... |
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Na(+)/K(+)-ATPase inhibition upregulates NMDA-evoked currents in rat hippocampal CA1 pyramidal neurons.
Fundam. Clin. Pharmacol. 26(4) , 503-12, (2012) Na(+)/K(+)-ATPase and N-methyl-D-aspartate (NMDA) receptor in hippocampus play very important roles in the regulation of learning and memory. Here, we showed that dihydroouabain (DHO, 10(-5)-10(-3) M), a Na(+)/K(+)-ATPase inhibitor, significantly potentiated ... |
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Contribution of cytosolic ionic and energetic milieu change to ischemia- and reperfusion-induced injury in guinea pig heart: fluorometry and nuclear magnetic resonance studies.
J. Cardiovasc. Pharmacol. 31(1) , 146-56, (1998) The contribution of cytosolic ion and energy milieu changes to ischemia/reperfusion injury was investigated in isolated guinea-pig hearts and mitochondria, with fluorometry and 31P nuclear magnetic resonance (NMR). The fura-2 Ca2+ signal during ischemia in th... |
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Isoform-specific function and distribution of Na/K pumps in the frog lens epithelium.
J. Membr. Biol. 178(2) , 89-101, (2000) Epithelial cells from the anterior and equatorial surfaces of the frog lens were isolated and used the same day for studies of the Na/K ATPase. RNase protection assays showed that all cells express alpha(1)- and alpha(2)-isoforms of the Na/K pump but not the ... |
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Novel form of LTD induced by transient, partial inhibition of the Na,K-pump in rat hippocampal CA1 cells.
J. Neurophysiol. 91(1) , 239-47, (2004) We tested the hypothesis that transient, partial inhibition of the Na,K-pumps could produce lasting effects on synaptic efficacy in brain tissue by applying a low concentration of the ouabain analogue, dihydroouabain (DHO), to hippocampal slices for 15 min an... |
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Mammalian cardenolides in cancer prevention and therapeutics.
Ther. Drug Monit. 30(2) , 234-8, (2008) Digoxin-like immunoreactive factor (DLIF) and ouabain-like factor (OLF) are the mammalian counterparts to the plant-derived cardiotonic steroids digoxin and ouabain. Compelling evidence indicates that the cardiotonic steroids may have anticancer properties. R... |
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Inhibition of Na(+)-K+ pump alleviates the shortening of action potential duration caused by metabolic inhibition via blockade of KATP channels in coronary perfused ventricular muscles of guinea-pigs.
J. Mol. Cell. Cardiol. 31(3) , 533-42, (1999) The Na(+)-K+ pump is a consumer of intracellular ATP. We therefore examined whether blockade of the Na(+)-K+ pump by cardiac glycosides could inhibit ATP-sensitive K+ (KATP) channels and prolong the action potential duration (APD) of the guinea-pig ventricula... |
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Dual effect of initial [K] on vascular tone in rat mesenteric arteries.
Pflugers Arch. 453(1) , 33-41, (2006) A slight increase in extracellular concentration of potassium ([K(+)](o)) can act as a vasodilator in rat mesenteric vascular bed. However, in recent years, several groups have failed to consistently observe relaxation of rat mesenteric arteries in these cond... |
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Two biologically active isomers of dihydroouabain isolated from a commercial preparation.
Biochim. Biophys. Acta 1472(3) , 486-97, (1999) Ouabain is a plant-derived cardiac glycoside that inhibits the catalytic activity of Na(+),K(+)-ATPase (sodium pump; NKA). Dihydroouabain, a derivative of ouabain with a reduced lactone ring, is commonly used as a sodium pump antagonist. It has been assumed t... |
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Different effects of low and high dose cardiotonic steroids on cytosolic calcium in spontaneously active hippocampal neurons and in co-cultured glia.
Brain Res. 795(1-2) , 325-40, (1998) The Na+ pump is crucial for the regulation of [Na+]i (the intracellular Na+ concentration) in all cells. Three Na+ pump alpha subunit isoforms, alpha1, alpha2 and alpha3, are expressed in rat hippocampal neurons, and alpha1 and alpha2 are expressed in glia, b... |