L(-)-Tryptophan
L(-)-Tryptophan structure
|
Common Name | L(-)-Tryptophan | ||
|---|---|---|---|---|
| CAS Number | 73-22-3 | Molecular Weight | 204.23 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 447.9±35.0 °C at 760 mmHg | |
| Molecular Formula | C11H12N2O2 | Melting Point | 289-290 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 224.7±25.9 °C | |
|
High-throughput fluorescence-based screening assays for tryptophan-catabolizing enzymes.
J. Biomol. Screen. 19(9) , 1266-74, (2014) Indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO) are two structurally different enzymes that have a different tissue distribution and physiological roles, but both catalyze the conversion of tryptophan to N-formylkynurenine (NFK). IDO1 ... |
|
|
Improved characterization of EV preparations based on protein to lipid ratio and lipid properties.
PLoS ONE 10(3) , e0121184, (2015) In recent years the study of extracellular vesicles has gathered much scientific and clinical interest. As the field is expanding, it is becoming clear that better methods for characterization and quantification of extracellular vesicles as well as better sta... |
|
|
Development of High-purity Certified Reference Materials for 17 Proteinogenic Amino Acids by Traceable Titration Methods.
Anal. Sci. 31 , 805-14, (2015) To ensure the reliability of amino acid analyses, the National Metrology Institute of Japan of the National Institute of Advanced Industrial Science and Technology (NMIJ/AIST) has developed high-purity certified reference materials (CRMs) for 17 proteinogenic... |
|
|
Seasonal postembryonic maturation of the diurnal rhythm of serotonin in the chicken pineal gland.
Chronobiol. Int. 32(1) , 59-70, (2015) Previously, we have demonstrated the postembryonic development of chicken (Gallus gallus domesticus L.) pineal gland functions expressed as changes in melatonin (MEL) biosynthesis. Pineal concentrations of MEL and its precursor serotonin (5-HT) were shown to ... |
|
|
Assessment of protein modifications in liver of rats under chronic treatment with paracetamol (acetaminophen) using two complementary mass spectrometry-based metabolomic approaches.
J. Proteomics 120 , 194-203, (2015) Liver protein can be altered under paracetamol (APAP) treatment. APAP-protein adducts and other protein modifications (oxidation/nitration, expression) play a role in hepatotoxicity induced by acute overdoses, but it is unknown whether liver protein modificat... |
|
|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
|
|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
|
|
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes.
J. Nutr. 145(1) , 87-95, (2015) The use of oral contraceptives (OCs) has been associated with low plasma pyridoxal 5'-phosphate (PLP). The functional consequences are unclear.To determine whether functional vitamin B-6 insufficiency occurs in OC users and is attributable to OCs, we investig... |
|
|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
|
|
Evaluation of an electrochemical biosensor for uric acid measurement in human whole blood samples.
Clin. Chim. Acta 436 , 72-7, (2014) Uric acid measurement has become increasingly important, and electrochemically modified detection method based portable devices hold a dominant position in the market for point of care and self-monitoring of uric acid blood levels. However, there has been a l... |