L(-)-Tryptophan

Modify Date: 2026-06-30 17:43:09

L(-)-Tryptophan structure	Common Name	L(-)-Tryptophan
	CAS Number	73-22-3	Molecular Weight	204.23
	Density	1.4±0.1 g/cm3	Boiling Point	447.9±35.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₂N₂O₂	Melting Point	289-290 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	224.7±25.9 °C

Use of L(-)-Tryptophan

L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	L-tryptophan
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
References	[1]. Slominski A, et al. Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. FEBS Lett. 2002 Jan 30;511(1-3):102-6.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.4±0.1 g/cm3
Boiling Point	447.9±35.0 °C at 760 mmHg
Melting Point	289-290 °C (dec.)(lit.)
Molecular Formula	C₁₁H₁₂N₂O₂
Molecular Weight	204.23
Flash Point	224.7±25.9 °C
Exact Mass	204.089874
PSA	79.11000
LogP	1.04
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.698
InChIKey	QIVBCDIJIAJPQS-VIFPVBQESA-N
SMILES	NC(Cc1c[nH]c2ccccc12)C(=O)O

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

L(-)-Tryptophan MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YN6130000

CHEMICAL NAME :: Tryptophan, L-

CAS REGISTRY NUMBER :: 73-22-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 29

MOLECULAR FORMULA :: C11-H12-N2-O2

MOLECULAR WEIGHT :: 204.25

WISWESSER LINE NOTATION :: T56 BMJ D1YZVQ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 10960 mg/kg/20W-I

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - eosinophilia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 2700 mg/kg/13W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - acute pulmonary edema Blood - eosinophilia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 3276 mg/kg/9W-I

TOXIC EFFECTS :: Behavioral - muscle weakness Blood - eosinophilia Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 9 gm/kg/22W-I

TOXIC EFFECTS :: Behavioral - muscle weakness Liver - liver function tests impaired Blood - eosinophilia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - antianxiety

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 857 mg/kg/30D-I

TOXIC EFFECTS :: Blood - eosinophilia Musculoskeletal - other changes Skin and Appendages - other glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 4800 mg/kg/34W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - paresthesis Blood - eosinophilia Skin and Appendages - other glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 5400 mg/kg/134W-I

TOXIC EFFECTS :: Blood - eosinophilia Skin and Appendages - other glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >16 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - coma Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1634 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2553 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - cyanosis Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4800 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - domestic

DOSE/DURATION :: 2410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 72 gm/kg/30D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - urine volume increased Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 30 gm/kg/30D-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9500 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 200 mg/kg

SEX/DURATION :: female 18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 900 mg/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 100 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,337,1985 *** REVIEWS *** TOXICOLOGY REVIEW BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 24,253,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3075 No. of Facilities: 1257 (estimated) No. of Industries: 6 No. of Occupations: 19 No. of Employees: 24809 (estimated) No. of Female Employees: 18622 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F
Risk Phrases	33-40-62-41-37/38-36/37/38-22
Safety Phrases	24/25-36/37/39-36-26
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	YN6130000
HS Code	2933990090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 6
CAS#:7479-05-2 h-d-trp-oet hcl CAS#:54-12-6 DL-Tryptophan CAS#:392-12-1 Indole-3-pyrubate CAS#:4384-87-6 indole-3-pyruvate
CAS#:35737-15-6 Fmoc-Trp-OH CAS#:1218-34-4 Acetyl-L-tryptophan
DownStream 10
CAS#:109690-46-2 6-METHOXY-3-MET... CAS#:112037-79-3 1-(trifluoromet... CAS#:120-72-9 Indole CAS#:3131-52-0 1H-Indole-5,6-diol
CAS#:92-88-6 4,4'-Dihydroxyb... CAS#:156-39-8 4-Hydroxyphenyl... CAS#:3569-19-5 5,6,3-trihydrox... CAS#:118-92-3 Anthranilic acid
CAS#:33468-35-8 6-Chloro-L-tryp... CAS#:5470-37-1 1H-Pyrido[3,4-b...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

High-throughput fluorescence-based screening assays for tryptophan-catabolizing enzymes.

J. Biomol. Screen. 19(9) , 1266-74, (2014)

Indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO) are two structurally different enzymes that have a different tissue distribution and physiological roles, but both catalyze the ...

Improved characterization of EV preparations based on protein to lipid ratio and lipid properties.

PLoS ONE 10(3) , e0121184, (2015)

In recent years the study of extracellular vesicles has gathered much scientific and clinical interest. As the field is expanding, it is becoming clear that better methods for characterization and qua...

Development of High-purity Certified Reference Materials for 17 Proteinogenic Amino Acids by Traceable Titration Methods.

Anal. Sci. 31 , 805-14, (2015)

To ensure the reliability of amino acid analyses, the National Metrology Institute of Japan of the National Institute of Advanced Industrial Science and Technology (NMIJ/AIST) has developed high-purit...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

MFCD00064340

EINECS 200-795-6

8,11-Dichloro-5H-dibenzo[b,e][1,4]diazepine

L(-)-Tryptophan

H-Trp-OH

Tadalafil Impurity 2

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the uses of L-tryptophan?

A: Main uses of L-tryptophan: L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

Q: What are the upstream materials of L-tryptophan?

A: Related upstream materials(CAS) of L-tryptophan: 7479-05-2;54-12-6;392-12-1;4384-87-6;35737-15-6;1218-34-4.

Q: What is the molecular formula of L-tryptophan?

A: Molecular formula of L-tryptophan is C11H12N2O2.

Q: What is the SMILES notation of L-tryptophan?

A: SMILES notation of L-tryptophan is NC(Cc1c[nH]c2ccccc12)C(=O)O.

Q: What is the molecular weight of L-tryptophan?

A: Molecular weight of L-tryptophan is 204.23.

Q: What is the English name of L-tryptophan?

A: The English name of L-tryptophan is L-tryptophan.

Q: What is the polar surface area (PSA) of L-tryptophan?

A: Polar surface area (PSA) of L-tryptophan is 79.11000.

Q: What is the melting point of L-tryptophan?

A: Melting point of L-tryptophan is 289-290 °C (dec.)(lit.).

Q: What is the LogP of L-tryptophan?

A: LogP of L-tryptophan is 1.04.

Q: What is the boiling point of L-tryptophan?

A: Boiling point of L-tryptophan is 447.9±35.0 °C at 760 mmHg.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

BioBioPha

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: L(-)-Tryptophan
Price: Check
Purity: 98.0%
Delivery: 10 Day
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BioBioPha
China
Product Name: L(-)-Tryptophan
Price: ￥Inquiry/5mg
Purity: 93.0%
Delivery: 10 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L-Tryptophan
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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L(-)-Tryptophan

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L(-)-Tryptophan | FAQ

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