CGP 39551
CGP 39551 structure
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Common Name | CGP 39551 | ||
|---|---|---|---|---|
| CAS Number | 127910-32-1 | Molecular Weight | 237.19 | |
| Density | 1.312 g/cm3 | Boiling Point | 434.1ºC at 760 mmHg | |
| Molecular Formula | C8H16NO5P | Melting Point | 236-239ºC | |
| MSDS | USA | Flash Point | 216.3ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Competitive NMDA receptor antagonists and agonists: effects on spontaneous alternation in mice exposed to cerebral oligemia.
Pol. J. Pharmacol. 56(1) , 59-66, (2004) The purpose of the present study was to investigate the effects of competitive NMDA receptor antagonists,D,L-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid (CGP 37849) and its ethyl ester (CGP 39551), or agonist, N-methyl-D-aspartate (NMDA) on spontaneous ... |
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NMDA receptor antagonists acting at the glycineB site in rat models for antipsychotic-like activity.
J. Neural Transm. Gen. Sect. 106(11-12) , 1189-204, (1999) Several partial agonist and full antagonists acting at the glycine site of the NMDA receptors were tested for potential antipsychotic-like properties in rats. As models, amphetamine- and phencyclidine (PCP)-induced locomotor activation in the open field and P... |
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Effects of competitive NMDA receptor antagonists on excitatory amino acid-evoked currents in mouse spinal cord neurones.
Fundam. Clin. Pharmacol. 13(1) , 67-74, (1999) The effects of CGP 37849 [DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoate] and its ethylester CGP 39551 on whole-cell currents evoked by the endogenous excitatory amino acids, L-glutamate and L-aspartate, were studied in cultured mouse spinal cord neurones. ... |
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Effect of CGP39551 administration on the kindling of ethanol-withdrawal seizures.
Psychopharmacology 163(2) , 157-65, (2002) It has previously been shown that drugs, such as benzodiazepines, that inhibit seizure activity during ethanol withdrawal, fail to alleviate the potentiated withdrawal seen following repeated episodes of withdrawal when administered during each withdrawal epi... |
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Chronic pre-explant blockade of the NMDA receptor affects survival of cerebellar granule cells explanted in vitro.
Brain Res. Dev. Brain Res. 99(1) , 112-7, (1997) Rat pups were treated with the competitive NMDA antagonist CGP 39551 with daily injections on postnatal days 1 to 8. Cultures of cerebellar granule cells were prepared from these pups as well as from control pups of the same age and body weight. Granule neuro... |
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Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. IV. Effects of CGP 39551.
Pharmacol. Biochem. Behav. 56(3) , 493-8, (1997) We determined anticonvulsant effects of CGP 39551 [(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid 1-ethylester] against pentylenetetrazol-induced seizures in developing, 7-90 day old, rats. The rats received CGP 39551 in doses of 10, 20 or 40 mg/kg IP 30 m... |
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Effects of the competitive N-methyl-D-aspartate antagonist CGP 37849 and its ethylester CGP 39551 on N-methyl-D-aspartate-evoked whole-cell currents in cultured spinal neurones and on vestibular stimulation-induced seizures in EL mice.
Arzneimittelforschung 48(12) , 1121-5, (1998) The competitive N-methyl-D-aspartate (NMDA) antagonist DL-2-amino-4-methyl-5-phosphono-3-pentenoic acid (CAS 127910-31-0, 4-methyl-APPA, CGP 37849) and its ethyl ester (CAS 127910-32-1, CGP 39551) potently block NMDA-evoked whole-cell current on mouse spinal ... |
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Neuronal nitric oxide synthase is permanently decreased in the cerebellum of rats subjected to chronic neonatal blockade of N-methyl-D-aspartate receptors.
Neurosci. Lett. 258(1) , 1-4, (1998) Pharmacological blockade of the (NMDA) receptor at critical stages of brain development may have long-lasting effects on brain chemistry and on animal behavior. We report here experiments in which the competitive NMDA receptor antagonist CGP 39551 was adminis... |
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Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats.
Brain Res. 734(1-2) , 91-7, (1996) Two selective excitatory amino acid antagonists, DL-(E)-2-amino-4-methyl- 5-phosphono-3-pentenoic acid (CGP 37849) and its carboxyethylester (CGP 39551), were studied against audiogenic seizures in genetically epilepsy-prone rats following oral administration... |
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CGP 37849 and CGP 39551: novel competitive N-methyl-D-aspartate receptor antagonists with potent oral anticonvulsant activity.
Prog. Clin. Biol. Res. 361 , 421-7, (1990)
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