methamidophos
methamidophos structure
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Common Name | methamidophos | ||
|---|---|---|---|---|
| CAS Number | 10265-92-6 | Molecular Weight | 141.129 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 208.7±23.0 °C at 760 mmHg | |
| Molecular Formula | C2H8NO2PS | Melting Point | 44.5°C | |
| MSDS | Chinese USA | Flash Point | 80.0±22.6 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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Development of an analytical method for the targeted screening and multi-residue quantification of environmental contaminants in urine by liquid chromatography coupled to high resolution mass spectrometry for evaluation of human exposures.
Talanta 146 , 694-706, (2015) The aim of this study was to develop an analytical method and contribute to the assessment of the Exposome. Thus, a targeted analysis of a wide range of contaminants in contact with humans on daily routines in urine was developed. The method focused on a list... |
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Development of a more specific and accurate multiple reaction monitoring method based on GC-EI/MS/MS for simultaneously monitoring and determining 34 kinds of pesticides in Qianjinzhidai pills.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 983-984 , 47-54, (2015) A rapid and accurate multi-residue method was developed for simultaneously monitoring and determining 34 kinds of pesticides by GC-EI/MS/MS, successfully applied in Qianjinzhidai pills. Precision, repeatability, stability, limit of detection (LOD), limit of q... |
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Japanese quail acute exposure to methamidophos: experimental design, lethal, sub-lethal effects and cholinesterase biochemical and histochemical expression.
Sci. Total Environ. 450-451 , 334-47, (2013) We exposed the Japanese quail (Coturnix coturnix japonica) to the organophosphate methamidophos using acute oral test. Mortality and sub-lethal effects were recorded in accordance to internationally accepted protocols. In addition cholinesterases were biochem... |
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Biochemical, histopathological and clinical evaluation of delayed effects caused by methamidophos isoforms and TOCP in hens: ameliorative effects using control of calcium homeostasis.
Toxicology 302(1) , 88-95, (2012) This work evaluated the potential of the isoforms of methamidophos to cause organophosphorus-induced delayed neuropathy (OPIDN) in hens. In addition to inhibition of neuropathy target esterase (NTE) and acetylcholinesterase (AChE), calpain activation, spinal ... |
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Selective solid-phase extraction using molecularly imprinted polymer for analysis of methamidophos in water and soil samples.
Biosci. Biotechnol. Biochem. 75(3) , 473-9, (2011) An analytical methodology for the analysis of methamidophos in water and soil samples incorporating a molecularly imprinted solid-phase extraction process using methamidophos-imprinted polymer was developed. Binding study demonstrated that the polymer exhibit... |
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Chlorpyrifos is associated with slower serum cholinesterase recovery in acute organophosphate-poisoned patients.
Clin. Toxicol. (Phila.) 51(5) , 402-8, (2013) Organophosphate poisoning (OPP) accounts for 200,000 deaths annually in developing countries. Serum cholinesterase (SChE) is of diagnostic value in patients with OPP and is checked repeatedly during the course of treatment. This study aimed to investigate the... |
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Acute exposure to the insecticide O,S-dimethyl phosphoramidothioate (methamidophos) leads to impairment of cardiovascular reflexes in rats.
Ecotoxicol. Environ. Saf. 80 , 203-7, (2012) Poisoning by organophosphorus insecticides is often accompanied by cardiac complications which may be serious and even fatal. However, the effects of these compounds on the cardiovascular mechanisms involved in blood pressure regulation are not known. The aim... |
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Effect of different oximes on rat and human cholinesterases inhibited by methamidophos: a comparative in vitro and in silico study.
Basic Clin Pharmacol Toxicol. 111(6) , 362-70, (2012) Methamidophos is one of the most toxic organophosphorus (OP) compounds. It acts via phosphorylation of a serine residue in the active site of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), leading to enzyme inactivation. Different oximes have b... |
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IR, Raman and SERS spectral analysis and DFT calculations on the Herbicide O,S-Dimethyl phosphoramidothioate, metamidophos.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 114 , 120-8, (2013) Infrared, Raman and SERS spectra of O,S-Dimethyl phosphoramidothioate, metamidophos, MAP, have been recorded. Density Functional Theory, DFT, with the B3LYP functional was used for the optimization of the ground state geometry and simulation of the infrared a... |
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Isatin-3-N4-benzilthiosemicarbazone, a non-toxic thiosemicarbazone derivative, protects and reactivates rat and human cholinesterases inhibited by methamidophos in vitro and in silico.
Toxicol. In Vitro 26(6) , 1030-9, (2012) Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. The inactivation of AChE results in the accumulation of acetylcholine at cholinergic receptor sites, causing a cholinergi... |