MEG hemisulfate
MEG hemisulfate structure
|
Common Name | MEG hemisulfate | ||
|---|---|---|---|---|
| CAS Number | 3979-00-8 | Molecular Weight | 336.456 | |
| Density | N/A | Boiling Point | 645.7ºC at 760 mmHg | |
| Molecular Formula | C6H20N6O4S3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 344.3ºC | |
|
Nitric oxide is synthesized in acute leukemia cells after exposure to phenolic antioxidants and initially protects against mitochondrial membrane depolarization.
Cancer Lett. 215(1) , 43-52, (2004) We investigated the early events involved in loss of mitochondrial membrane potential (DeltaPsi(mt)) leading to apoptosis in cells derived from patients with acute lymphocytic leukemia after exposure to phenolic antioxidants. Using the nitric oxide binding dy... |
|
|
Mitogen-activated protein kinase phosphorylation in kidneys of beta(s) sickle cell mice.
J. Am. Soc. Nephrol. 11(6) , 1026-32, (2000) Previous studies in beta(s) sickle cell mice demonstrated renal immunostaining for nitrotyrosine, which is putative evidence of peroxynitrite (ONOO(-)) formation. ONOO(-) is known to nitrate tyrosine residues of various enzymes, thereby interfering with phosp... |
|
|
Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys.
Kidney Int. 58(1) , 82-9, (2000) In previous studies of transgenic sickle cell mice, increased renal expression of inducible nitric oxide synthase (iNOS) and endothelial cell isoform of NOS (EcNOS) was found by Western blot and immunohistochemistry. In addition, putative evidence of peroxyni... |
|
|
Scavenging of peroxynitrite reduces renal ischemia/reperfusion injury.
Ren. Fail. 30(7) , 747-54, (2008) Nitric oxide (NO) and peroxynitrite (OONO-) are implicated in the pathophysiology of renal ischemia/reperfusion (I/R). The aim of this study was to investigate and compare the efficiency of S-methylisothiourea (SMT), an iNOS inhibitor, and mercaptoethylguanid... |
|
|
Inhibition of experimental gingivitis in beagle dogs with topical mercaptoalkylguanidines.
J. Periodontol. 77(3) , 385-91, (2006) Nitric oxide is a free radical produced in host tissues by constitutive and inducible forms of the enzyme nitric oxide synthase. Nitric oxide plays physiological roles, but it is also involved in the pathophysiology of several inflammatory conditions, includi... |
|
|
Mercaptoethylguanidine attenuates inflammation in bacterial meningitis in rabbits.
Life Sci. 67(4) , 365-72, (2000) Reactive oxygen and nitrogen species participate in the inflammatory process during meningitis. Among them, superoxide, nitric oxide (NO), and their reaction product peroxynitrite exert cytotoxic effects. Mercaptoethylguanidine (MEG) exerts beneficial effects... |
|
|
Neuroprotective effects of mercaptoethylleonurine and mercaptoethylguanidine analogs on hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells.
Bioorg. Med. Chem. Lett. 23(6) , 1793-6, (2013) A series of mercaptoethylleonurine and mercaptoethylguanidine derivatives were designed and synthesized. Their neuroprotective effects toward H2O2-induced apoptosis were investigated in human SH-SY5Y cells. The results from these studies identified several po... |
|
|
Mercaptoethylguanidine attenuates caustic esophageal injury in rats: a role for scavenging of peroxynitrite.
J. Pediatr. Surg. 46(9) , 1746-52, (2011) After ingestion of caustic material, tissue damage is caused by reactive oxygen species and reactive nitrogen species such as peroxynitrite. Mercaptoethylguanidine (MEG) is a well-known scavenger of peroxynitrite. This study was designed to determine whether ... |
|
|
Effect of mercaptoethylguanidine scavengers of peroxynitrite on the development of experimental allergic encephalomyelitis in PLSJL mice.
Neurosci. Lett. 311(2) , 125-8, (2001) Peroxynitrite has been implicated in the pathogenesis of multiple sclerosis and its animal counterpart experimental allergic encephalomyelitis (EAE). Here we have examined the effects of the novel peroxynitrite scavengers, mercaptoethylguanidine (MEG) and gua... |
|
|
Modulation of peroxynitrite- and hypochlorous acid-induced inactivation of alpha1-antiproteinase by mercaptoethylguanidine.
Br. J. Pharmacol. 126(7) , 1646-52, (1999) 1. Peroxynitrite is a cytotoxic species that can be formed, among other mechanisms, by the rapid reaction of superoxide with nitric oxide. Peroxynitrite formation has been implicated in a wide range of neurodegenerative and chronic inflammatory diseases, as h... |