Naphthalen-2-amine
Naphthalen-2-amine structure
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Common Name | Naphthalen-2-amine | ||
|---|---|---|---|---|
| CAS Number | 91-59-8 | Molecular Weight | 143.185 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 307.5±11.0 °C at 760 mmHg | |
| Molecular Formula | C10H9N | Melting Point | 111-113 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 157.1±14.6 °C | |
| Symbol |
GHS07, GHS08, GHS09 |
Signal Word | Danger | |
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cIEF for rapid pKa determination of small molecules: a proof of concept.
Eur. J. Pharm. Sci. 63 , 14-21, (2014) A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) were compared: (i) a hydroxypropylcellulose (HPC) coated cap... |
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5-Amino-1-naphthol, a novel 1,5-naphthalene derivative matrix suitable for matrix-assisted laser desorption/ionization in-source decay of phosphorylated peptides.
Rapid Commun. Mass Spectrom. 27(1) , 103-8, (2013) Although matrix-assisted laser desorption/ionization in-source decay (MALDI-ISD) is an important method for post-translational modification (PTM) analysis, the conventional matrices, 2,5-dihydroxybenzoic acid (2,5-DHB) and 1,5-diaminonaphthalene (1,5-DAN), ar... |
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Discrimination of isobaric Leu/Ile residues by MALDI in-source decay mass spectrometry.
J. Am. Soc. Mass Spectrom. 24(2) , 297-300, (2013) MALDI in-source decay (ISD) has been used for top-down sequencing of proteins. The use of the matrix 1,5-diaminonapthalene (1,5-DAN) gave abundant w ions, which are formed from the unimolecular dissociation of z• radical fragments via α cleavage reaction and ... |
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Ultraviolet laser induced hydrogen transfer reaction: study of the first step of MALDI in-source decay mass spectrometry.
J. Phys. Chem. B 117(8) , 2321-7, (2013) The early mechanisms of matrix-assisted laser desorption/ionization in-source decay (MALDI-ISD) are described herein. MALDI-ISD is initiated by the hydrogen transfer from excited matrix molecules to the carbonyl oxygen of the peptide backbone, which is follow... |
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Toxicological assessment of kretek cigarettes: Part 1: background, assessment approach, and summary of findings.
Regul Toxicol Pharmacol 70 Suppl 1 , S2-14, (2014) This publication introduces a series of six other publications describing the toxicological assessment of kretek cigarettes, i.e., cigarettes characterized primarily by the use of a significant amount of cloves as an ingredient added to the tobacco. This pape... |
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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
J. Med. Chem. 50 , 742-8, (2007) The development of in silico and in vitro tools to estimate or predict the passive human skin permeation and distribution of new chemical entities, useful in dermal drug delivery, in absorption studies of toxic compounds, and in the cosmetics industry, is pre... |
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Segregative clustering of Lo and Ld membrane microdomains induced by local pH gradients in GM1-containing giant vesicles: a lipid model for cellular polarization.
Langmuir 28(47) , 16327-37, (2012) Several cell polarization processes are coupled to local pH gradients at the membrane surface. We have investigated the involvement of a lipid-mediated effect in such coupling. The influence of lateral pH gradients along the membrane surface on lipid microdom... |
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Lo/Ld phase coexistence modulation induced by GM1.
Biochim. Biophys. Acta 1838(8) , 2105-14, (2014) Lipid rafts are assumed to undergo biologically important size-modulations from nanorafts to microrafts. Due to the complexity of cellular membranes, model systems become important tools, especially for the investigation of the factors affecting "raft-like" L... |
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Electrochemical detection of the amino-substituted naphthalene compounds based on intercalative interaction with hairpin DNA by electrochemical impedance spectroscopy.
Biosens. Bioelectron. 48 , 238-43, (2013) The amino-substituted naphthalene compounds, such as 1,8-diaminonaphthalene (1,8-DANAP), 2,3-diaminonaphthalene (2,3-DANAP), 1,5-diaminonaphthalene (1,5-DANAP), 1-naphthylamine (1-NAP) and 2-naphthylamine (2-NAP), were investigated by electrochemical impedanc... |
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A novel fluorescent sensor protein for detecting changes in airway surface liquid glucose concentration.
Biochem. J. 464(2) , 213-20, (2014) Both lung disease and elevation of blood glucose are associated with increased glucose concentration (from 0.4 to ~4.0 mM) in the airway surface liquid (ASL). This perturbation of ASL glucose makes the airway more susceptible to infection by respiratory patho... |