Azathioprine
Azathioprine structure
|
Common Name | Azathioprine | ||
|---|---|---|---|---|
| CAS Number | 446-86-6 | Molecular Weight | 277.263 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 685.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C9H7N7O2S | Melting Point | 243-244°C | |
| MSDS | Chinese USA | Flash Point | 368.5±31.5 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
|
Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion.
Cancer Res. 75 , 2907-15, (2015) Pancreatic cancer, one of the most lethal forms of human cancer, is largely resistant to many conventional chemotherapeutic agents. Although many therapeutic approaches focus on tumor growth, metastasis is a primary factor contributing to lethality. Therefore... |
|
|
Risk of merkel cell carcinoma after solid organ transplantation.
J. Natl. Cancer Inst. 107(2) , doi:10.1093/jnci/dju382, (2015) Solid organ transplant recipients have elevated risks of virus-related cancers, in part because of long-term immunosuppression. Merkel cell carcinoma (MCC) is an aggressive skin cancer recently found to have a viral origin, but little is known regarding the o... |
|
|
Recalcitrant hypocalcaemia in autoimmune enteropathy.
Pediatrics 134(6) , e1720-6, (2014) Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome is a monogenic disorder associated with autoimmune destruction of both endocrine and nonendocrine tissues. The classic triad includes candidiasis, hypoparathyroidism, and Addison disease.... |
|
|
Alloimmune responses and atherosclerotic disease after kidney transplantation.
Transplantation 99(1) , 220-5, (2014) Chronic exposure to exogenous antigens causes accumulation of proinflammatory CD57(+)CD28(-) hyperactivated CD8(+) T cells that may promote atherosclerosis. We hypothesized that persistent alloimmune responses may induce immune activation and contribute to po... |
|
|
Success with single-agent immunosuppression for multifocal choroidopathies.
Am. J. Ophthalmol. 158(6) , 1310-7, (2014) To evaluate the success of single-agent immunosuppression for patients with the posterior uveitides, birdshot chorioretinitis, multifocal choroiditis with panuveitis, and punctate inner choroiditis.Retrospective case series.setting: Tertiary care uveitis prac... |
|
|
Everolimus-based immunosuppression in patients with hepatocellular carcinoma at high risk of recurrence after liver transplantation: a case series.
Transplant. Proc. 46(10) , 3496-501, (2014) Liver transplantation offers the most effective treatment in patients with hepatocellular carcinoma (HCC). However, transplant patients outside the Milan criteria have a high risk of tumor recurrence, which has been linked to standard immunosuppression regime... |
|
|
Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents.
J. Am. Acad. Dermatol. 71(2) , 327-49, (2014) Atopic dermatitis is a chronic, pruritic inflammatory dermatosis that affects up to 25% of children and 2% to 3% of adults. This guideline addresses important clinical questions that arise in atopic dermatitis management and care, providing recommendations ba... |
|
|
Gingival pain: an unusual side effect of ziprasidone.
BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013) The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laboratory findings were unremarkable. He did not have any extra-pyr... |
|
|
Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans.
Cancer Prev. Res. (Phila.) 8 , 475-86, (2015) The transcription factor Nrf2 determines the ability to adapt and survive under conditions of electrophilic, oxidative, and inflammatory stress by regulating the expression of elaborate networks comprising nearly 500 genes encoding proteins with versatile cyt... |
|
|
IgE antibodies and skin tests in immediate hypersensitivity reactions to infliximab in inflammatory bowel disease: impact on infliximab retreatment.
Eur. J. Gastroenterol. Hepatol. 27 , 1200-8, (2015) Infliximab (IFX) is used for the treatment of inflammatory bowel diseases (IBD). Immediate hypersensitivity reactions (HR) to IFX are frequently reported.We investigated immunoglobulin E (IgE)-mediated mechanisms underlying immediate HR to IFX. We also evalua... |