2,6-pyridinediol, hydrochloride

2,6-pyridinediol, hydrochloride Structure
2,6-pyridinediol, hydrochloride structure
Common Name 2,6-pyridinediol, hydrochloride
CAS Number 10357-84-3 Molecular Weight 147.560
Density 1.379g/cm3 Boiling Point 387.2ºC at 760mmHg
Molecular Formula C5H6ClNO2 Melting Point 206-208 °C (dec.)(lit.)
MSDS USA Flash Point 188ºC
Symbol GHS07
GHS07
Signal Word Warning

[Estimation of pathways of 5-fluorouracil anabolism in human cancer cells in vitro and in vivo].

Gan To Kagaku Ryoho. 23(6) , 721-31, (1996)

Possible pathways of intracellular phosphorylation of 5-fluorouracil (5-FU) in human cancer cells were investigated in vitro and in vivo. We used two inhibitors which regulate the anabolism of 5-FU for the purpose of elucidation of its pathways; one is oxonic...

An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.

J. Bacteriol. 187(24) , 8516-9, (2005)

The enzyme catalyzing the hydrolytic cleavage of 2,6-dihydroxypseudooxynicotine to 2,6-dihydroxypyridine and gamma-N-methylaminobutyrate was found to be encoded on pAO1 of Arthrobacter nicotinovorans. The new enzyme answers an old question about nicotine cata...

Combination of the chemotherapeutic agent 5-fluorouracil with an inhibitor of its catabolism results in increased micronucleus induction.

Biochem. Biophys. Res. Commun. 203(2) , 1124-30, (1994)

The rate limiting step in 5-fluorouracil catabolism is catalyzed by the enzyme dihydropyrimidine dehydrogenase. Since degradation of 5-fluorouracil decreases its efficacy in chemotherapy, the inhibition of its catabolism is a promising tool. We investigated t...