DOPE
DOPE structure
|
Common Name | DOPE | ||
|---|---|---|---|---|
| CAS Number | 4004-05-1 | Molecular Weight | 744.034 | |
| Density | 1.008g/cm3 | Boiling Point | 759.2±70.0 °C at 760 mmHg | |
| Molecular Formula | C41H78NO8P | Melting Point | 200 °C | |
| MSDS | Chinese USA | Flash Point | 413.0±35.7 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Activation of Tomato Bushy Stunt Virus RNA-Dependent RNA Polymerase by Cellular Heat Shock Protein 70 Is Enhanced by Phospholipids In Vitro.
J. Virol. 89(10) , 5714-23, (2015) Similar to other positive-strand RNA viruses, tombusviruses are replicated by the membrane-bound viral replicase complex (VRC). The VRC consists of the p92 virus-coded RNA-dependent RNA polymerase (RdRp), the viral p33 RNA chaperone, and several co-opted host... |
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Insights from reconstitution reactions of COPII vesicle formation using pure components and low mechanical perturbation.
Biol. Chem. 395(7-8) , 801-12, (2014) As shape transformations of membranes are vital for intracellular trafficking, it is crucial to understand both the mechanics and the biochemistry of these processes. The interplay of these two factors constitutes an experimental challenge, however, because b... |
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Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections.
Pharm. Res. 32(5) , 1546-56, (2015) To investigate the suitability of three antimicrobial peptides (AMPs) as cell-penetrating antimicrobial peptides.Cellular uptake of three AMPs (PK-12-KKP, SA-3 and TPk) and a cell-penetrating peptide (penetratin), all 5(6)-carboxytetramethylrhodamine-labeled,... |
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Antibiotic delivery by liposomes from prokaryotic microorganisms: Similia cum similis works better.
Eur. J. Pharm. Biopharm. 94 , 411-8, (2015) To date the effectiveness of antibiotics is undermined by microbial resistance, threatening public health worldwide. Enhancing the efficacy of the current antibiotic arsenal is an alternative strategy. The administration of antimicrobials encapsulated in nano... |
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The p10 FAST protein fusion peptide functions as a cystine noose to induce cholesterol-dependent liposome fusion without liposome tubulation.
Biochim. Biophys. Acta 1848(2) , 408-16, (2014) The reovirus p10 fusion-associated small transmembrane (FAST) proteins are the smallest known membrane fusion proteins, and evolved specifically to mediate cell-cell, rather than virus-cell, membrane fusion. The 36-40-residue ectodomains of avian reovirus (AR... |
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In vitro transport activity of the fully assembled MexAB-OprM efflux pump from Pseudomonas aeruginosa.
Nat. Commun. 6 , 6890, (2015) Antibiotic resistance is a major public health issue and many bacteria responsible for human infections have now developed a variety of antibiotic resistance mechanisms. For instance, Pseudomonas aeruginosa, a disease-causing Gram-negative bacteria, is now re... |
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Development of anti-E6 pegylated lipoplexes for mucosal application in the context of cervical preneoplastic lesions.
Int. J. Pharm. 483(1-2) , 268-77, (2015) Cervical cancer induced by human papillomavirus (HPV) is the fourth highest mortality causing cancer in women despite the use of prophylactic vaccines. E6 targeting represents an attractive strategy to treat this cancer. Indeed, oncoprotein E6 is produced by ... |
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Interferon-β gene transfer induces a strong cytotoxic bystander effect on melanoma cells.
Biomed. Pharmacother. 72 , 44-51, (2015) A local gene therapy scheme for the delivery of type I interferons could be an alternative for the treatment of melanoma. We evaluated the cytotoxic effects of interferon-β (IFNβ) gene lipofection on tumor cell lines derived from three human cutaneous and fou... |
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Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems.
J. Phys. Chem. B 119 , 8698-706, (2015) Previous work has shown that lipid nanoparticles (LNP) composed of an ionizable cationic lipid, a poly(ethylene glycol) (PEG) lipid, distearoylphosphatidylcholine (DSPC), cholesterol, and small interfering RNA (siRNA) can be efficiently manufactured employing... |
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The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors.
Eur. J. Pharm. Biopharm. 88(2) , 539-50, (2014) Multicellular 3D cancer cell culture (spheroids) resemble to in vivo tumors in terms of shape, cell morphology, growth kinetics, gene expression and drug response. However, these characteristics cause very limited drug penetration into deeper parts of the sph... |