DPQ
DPQ structure
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Common Name | DPQ | ||
|---|---|---|---|---|
| CAS Number | 129075-73-6 | Molecular Weight | 302.41 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 528.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H26N2O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 273.6±30.1 °C | |
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DNA Double Strand Break Response and Limited Repair Capacity in Mouse Elongated Spermatids.
Int. J. Mol. Sci. 16 , 29923-35, (2015) Spermatids are extremely sensitive to genotoxic exposures since during spermiogenesis only error-prone non homologous end joining (NHEJ) repair pathways are available. Hence, genomic damage may accumulate in sperm and be transmitted to the zygote. Indirect, d... |
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Parp1-XRCC1 and the repair of DNA double strand breaks in mouse round spermatids.
Mol. Cell. 683 , 84-90, (2010) The repair of DNA double strand breaks (DSBs) in male germ cells is slower and differently regulated compared to that in somatic cells. Round spermatids show DSB repair and are radioresistant to apoptosis induction. Mutation induction studies using ionizing i... |
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Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.
Nat. Med. 3 , 1089, (1997) Nitric oxide (NO) and peroxynitrite, formed from NO and superoxide anion, have been implicated as mediators of neuronal damage following focal ischemia, but their molecular targets have not been defined. One candidate pathway is DNA damage leading to activati... |
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Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase.
Anticancer Drug Des. 6 , 107, (1991) A series of dihydroisoquinolinones, formally rigid analogs of 3-substituted benzamides, and a series of 2,3-disubstituted benzamides were synthesized and evaluated as inhibitors of poly(ADP-ribose) polymerase. The results indicated that the orientation of the... |