UNII:C19D0413EL
UNII:C19D0413EL structure
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Common Name | UNII:C19D0413EL | ||
|---|---|---|---|---|
| CAS Number | 56392-16-6 | Molecular Weight | 283.363 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 437.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H25NO4 | Melting Point | 65-67ºC | |
| MSDS | USA | Flash Point | 218.4±28.7 °C | |
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Simultaneous determination of metoprolol and α-hydroxymetoprolol in human plasma using excitation-emission matrix fluorescence coupled with second-order calibration methods.
Bioanalysis 4(23) , 2781-93, (2012) Metoprolol (MET) is a β1-adrenoceptor antagonist, which is widely used in the treatment of cardiovascular diseases, and α-hydroxymetoprolol (α-OHM) is its hydroxylated metabolite. Owing to their similar structures, optimization of the condition for the chroma... |
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Metoprolol oxidation polymorphism in Brazilian elderly cardiac patients.
J. Pharm. Pharmacol. 65(9) , 1347-53, (2013) The purpose of this study was to phenotype the CYP2D6 in elderly with heart disease classified as extensive metabolizer or poor metabolizers (PM) of metoprolol, develop and validate the method of analysis of metoprolol tartrate and its metabolite in urine usi... |
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Variation of pharmacokinetics after oral administration of slow-release metoprolol tablets and pharmacogenetic considerations.
Arzneimittelforschung 42(6) , 802-6, (1992) The maximum plasma concentrations (Cmax) after oral administration of 120 mg tablets of slow-release metoprolol (CAS 37350-58-6) to 75 Japanese healthy male volunteers and 15 arrhythmic patients were measured. Extensive and poor metabolizers after oral admini... |
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Utility of a one-point (3-hour postdose) plasma metabolic ratio as a phenotyping test using metoprolol in two east Asian populations.
Ther. Drug Monit. 14(3) , 184-9, (1992) We examined the utility of the postdose 3-h plasma metabolic ratio (MR) as a phenotyping method for assessing genetically determined debrisoquine-type oxidation polymorphism after an oral dose of 100 mg of metoprolol tartrate administered to 402 unrelated, he... |
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Simultaneous RP-HPLC determination of sotalol, metoprolol, alpha-hydroxymetoprolol, paracetamol and its glucuronide and sulfate metabolites in human urine.
Anal. Sci. 25(6) , 769-72, (2009) The HPLC method for the determination of sotalol (SOT), metoprolol (MET) and alpha-hydroxymetoprolol metabolite (MET-H), paracetamol (PAR), paracetamol glucuronide (PAR-G) and paracetamol sulfate (PAR-S) in human urine is described. Analyses were carried out ... |
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Effects and pharmacokinetics of high dose metoprolol on chest pain in patients with suspected or definite acute myocardial infarction.
Eur. J. Clin. Pharmacol. 53(1) , 23-31, (1997) Pain intensity and the plasma concentrations of metoprolol and its major metabolite alpha-hydroxymetoprolol as well as noradrenaline (NA), adrenaline (A) and neuropeptide Y (NPY) were determined in patients with pain due to definite or suspected acute myocard... |
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Influence of CYP2D6*10 on the pharmacokinetics of metoprolol in healthy Korean volunteers.
J. Clin. Pharm. Ther. 33(5) , 567-73, (2008) Genetic polymorphism of CYP2D6 leads to differences in pharmacokinetics of CYP2D6 substrates. The CYP2D6*10 allele is clinically important in Koreans because of its high frequency in Asians. We investigated whether the pharmacokinetics of metoprolol was alter... |
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Influence of input rate on the stereospecific and nonstereospecific first pass metabolism and pharmacokinetics of metoprolol extended release formulations.
Chirality 14(4) , 297-304, (2002) The purpose of this study was to examine the influence of input rate on the stereoselective and nonstereoselective pharmacokinetics of metoprolol, alpha-hydroxymetoprolol, and its acid metabolite. Extended release formulations (100 mg) of metoprolol with vary... |
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Assay of metoprolol and alpha-hydroxymetoprolol in human urine by reversed-phase liquid chromatography with direct-injection.
Zhongguo Yao Li Xue Bao 16(1) , 32-5, (1995) To develop an HPLC method with direct injection for the simultaneous determination of metoprolol (M) and alpha-hydroxymetoprolol (HM) in human urine.Urine (200 microliters) was diluted with eluate and injected into the chromatograph. Samples were separated on... |
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Metoprolol alpha-hydroxylation capacity in 96 Chinese Han volunteers.
Zhongguo Yao Li Xue Bao 16(4) , 325-9, (1995) To study the ability of oxidizing metoprolol (Met) to form alpha-hydroxymetoprolol (HM) in Chinese in vivo and in vitro.An ion-pair reverse phase high performance liquid chromatography was used.In vivo study, the 8-h urinary recoveries of Met and HM after po ... |