Sulfadiazine
Sulfadiazine structure
|
Common Name | Sulfadiazine | ||
|---|---|---|---|---|
| CAS Number | 68-35-9 | Molecular Weight | 250.277 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 512.6±52.0 °C at 760 mmHg | |
| Molecular Formula | C10H10N4O2S | Melting Point | 253 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 263.8±30.7 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
|
|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
|
|
Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins
Bioorg. Med. Chem. 17 , 896-904, (2009) This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the mole... |
|
|
Fast determination of 22 sulfonamides from chicken breast muscle using core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer followed by liquid chromatography-tandem mass spectrometry.
J. Chromatogr. A. 1345 , 17-28, (2014) A novel, simple and sensitive method was developed for the simultaneous determination of 22 sulfonamides (SAs) in chicken breast muscle by using the dispersive micro-solid-phase extraction (d-μ-SPE) procedure combined with ultra-fast liquid chromatography-tan... |
|
|
Supported liquid membrane-protected molecularly imprinted beads for micro-solid phase extraction of sulfonamides in environmental waters.
J. Chromatogr. A. 1357 , 158-64, (2014) In this work, molecularly imprinted polymer (MIP) beads have been prepared and evaluated for the development of a supported liquid membrane-protected micro-solid phase extraction method for the analysis of sulfonamides (SAs) in aqueous samples. The performanc... |
|
|
Simultaneous determination of 38 veterinary antibiotic residues in raw milk by UPLC-MS/MS.
Food Chem. 181 , 119-26, (2015) A selective and rapid method has been developed to determine, simultaneously, 38 veterinary antibiotic residues in raw milk by ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). One milliliter of raw milk was diluted with 0.5 ... |
|
|
Concentration and distribution of antibiotics in water-sediment system of Bosten Lake, Xinjiang.
Environ. Sci. Pollut. Res. Int. 22(3) , 1670-8, (2015) This study investigated the residues of four sulfonamides, four quinolones, and four tetracyclines in surface water as well as surficial sediment samples, of Bosten Lake, in Xinjiang, China. The results showed the presence of 10 out of the 12 selected antibio... |
|
|
Cucurbit(6)uril immobilized on silica: a novel high-performance liquid chromatographic stationary phase.
J. Sep. Sci. 38(7) , 1082-9, (2015) In the present study, one of the new generation of host molecules, cucurbit(6)uril (CB(6)), was immobilized onto silica (CB(6)/SiO2 ) by a sol-gel approach. CB(6)/SiO2 was characterized by NMR spectroscopy, Fourier transform infrared spectroscopy, thermogravi... |
|
|
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data
Eur. J. Med. Chem. 44 , 4455-60, (2009) We developed an improved Lombardeo's method (J. Med. Chem., 2004) for prediction of VD ss in human. With Elog D substituted by log k IAM, together with f i (7.4) (the fraction of compound ionized at pH 7.4) and log f u (logarithmic fraction of compound unboun... |
|
|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
J. Med. Chem. 51 , 6740-51, (2008) The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives, and the theoretical pr... |