2-Phenyl-isoindole-1,3-dione
2-Phenyl-isoindole-1,3-dione structure
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Common Name | 2-Phenyl-isoindole-1,3-dione | ||
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| CAS Number | 520-03-6 | Molecular Weight | 223.227 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 388.8±25.0 °C at 760 mmHg | |
| Molecular Formula | C14H9NO2 | Melting Point | 204-207 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 182.6±15.5 °C | |
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Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening.
J. Med. Chem. 54 , 5454, (2011) To identify specific bacterial thymidylate synthase (TS) inhibitors, we exploited phenolphthalein (PTH), which inhibits both bacterial and human enzymes. The X-ray crystal structure of Lactobacillus casei TS (LcTS) that binds PTH showed multiple binding modes... |
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Phenylphthalimides with tumor necrosis factor alpha production-enhancing activity.
Chem. Pharm. Bull. 44(1) , 156-62, (1996) Phenylphthalimides (2-phenyl-1H-isoindole-1,3-diones) were prepared and their effects on tumor necrosis factor alpha (TNF-alpha) production by human leukemia cell line HL-60 stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) were examined. An analysis... |
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Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs.
Bioorg. Med. Chem. Lett. 9(4) , 559-62, (1999) A novel series of nonpeptide small-molecular dipeptidyl peptidase IV (DPP-IV) inhibitors with an N-phenylphthalimide skeleton has been developed. Some of the compounds, including 4-amino-(2,6-dimethylphenyl)phthalimides (7), 4- and 5-hydroxy-(2,6-diethylpheny... |
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N-phenylphthalimide-type cyclooxygenase (COX) inhibitors derived from thalidomide: substituent effects on subtype selectivity.
Chem. Pharm. Bull. 52(8) , 1021-2, (2004) Several N-substituted phenylphthalimide and phenylhomophthalimide derivatives with cyclooxygenase (COX)-inhibitory activity were prepared during structural development studies based on thalidomide as a lead compound. Substituent effects on the subtype selecti... |
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Development of tryptase inhibitors derived from thalidomide.
Bioorg. Med. Chem. 18(14) , 5323-38, (2010) A novel series of tryptase inhibitors with a N-phenylphthalimide skeleton structurally derived from thalidomide (1) has been developed. Structure-activity relationship studies led to a potent and selective tryptase inhibitor, 2-(4-cyanophenyl)isoindole-1,3-di... |
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Glycogen phosphorylase a inhibitors with a phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists.
Biol. Pharm. Bull. 32(9) , 1618-20, (2009) Novel glycogen phosphorylase a (GPa) inhibitors with a phenethylphenylphthalimide skeleton were prepared based on alpha-glucosidase inhibitors and liver X receptor (LXR) antagonists derived from thalidomide. Their structure-activity relationships were analyze... |
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[Preparation of novel specific aminopeptidase inhibitors with a cyclic imide skeleton].
Yakugaku Zasshi 120(10) , 909-21, (2000) The studies on both structure-activity relationship study and identification of the target enzyme of novel nonpeptide aminopeptidase inhibitors with cyclic imide skeleton are reviewed. Some N-phenylphthalimide or N-phenylhomophthalimide derivative showed pote... |
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The oxidative degradation of imide polymers. I: Ozonolysis of a model compound, N-phenylphthalimide. Barman S, et al.
Polym. Eng. Sci. 34(4) , 279-284, (1994)
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