N,N'-Diaminoguanidine
N,N'-Diaminoguanidine structure
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Common Name | N,N'-Diaminoguanidine | ||
|---|---|---|---|---|
| CAS Number | 36062-19-8 | Molecular Weight | 125.561 | |
| Density | 1.94g/cm3 | Boiling Point | 219.3ºC at 760mmHg | |
| Molecular Formula | CH8ClN5 | Melting Point | 180-182 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 86.5ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Inactivation of nitric oxide synthase isoforms by diaminoguanidine and NG-amino-L-arginine.
Arch. Biochem. Biophys. 325(2) , 227-34, (1996) Diaminoguanidine (DAG) and NG-amino-L-arginine each produced a time- and concentration-dependent inactivation of the citrulline-forming activity of all three NOS isoforms. DAG inactivates both the NADPH-oxidase and the citrulline-forming activities of GH3 pit... |
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Inhibition of nitric oxide formation by guanidines.
Eur. J. Pharmacol. 249(1) , 101-6, (1993) Aminoguanidine, N,N'-diaminoguanidine, methylguanidine, and 1,1-dimethylguanidine were compared to NG-monomethyl-L-arginine (L-NMMA) for their ability to inhibit nitric oxide (NO) formation by cytokine-inducible and vascular constitutive isoforms of NO syntha... |
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Affinity adsorption of glucose degradation products improves the biocompatibility of conventional peritoneal dialysis fluid.
Kidney Int. 63(1) , 331-9, (2003) Reactive carbonyl compounds (RCOs) present in peritoneal dialysis (PD) fluid have been incriminated in the progressive deterioration of the peritoneal membrane in long-term PD patients. They are initially present in fresh conventional heat-sterilized glucose ... |
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Inhibition of diabetes-associated complications by nucleophilic compounds.
Diabetes 40(8) , 1079-84, (1991) Mono- and diaminoguanidine inhibited ambient glucose-induced glycosylated end product formation of albumin and collagen 125I-labeled albumin covalent binding in vitro. Diaminoguanidine was a stronger inhibitor than monoaminoguanidine. These compounds also inh... |
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Polyamine catabolism is involved in response to salt stress in soybean hypocotyls.
J. Plant Physiol. 168(11) , 1234-40, (2011) The possible relationship between polyamine catabolism mediated by copper-containing amine oxidase and the elongation of soybean hypocotyls from plants exposed to NaCl has been studied. Salt treatment reduced values of all hypocotyl growth parameters. In vitr... |
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Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group.
Chem. Res. Toxicol. 18(12) , 1927-33, (2005) It is established that aminoguanidine (AG), diaminoguanidine (DAG), and NG-amino-l-arginine (NAA) are metabolism-based inactivators of the three major isoforms of nitric oxide synthase (NOS). In the case of neuronal NOS (nNOS), heme alteration is known to be ... |
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Reactions of N-N and N-O compounds with horseradish peroxidase and peroxidases from Mycobacterium tuberculosis.
APMIS 107(6) , 555-65, (1999) Several N-N-and N-O-containing compounds were analysed for their ability to act as substrates for horseradish peroxidase and peroxidases in Mycobacterium tuberculosis extracts. Aminoguanidine, diaminoguanidine, isoniazid, hydroxylamine and hydrazine were foun... |
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Aminoguanidine does not inhibit aldose reductase activity in galactose-fed rats.
J. Diabetes Complications 10(1) , 23-30, (1996) Aminoguanidine, nucleophilic hydrazine derivative, has been shown to inhibit diamine oxidase, the formation of advanced glycation endproducts, nitric oxide synthase, and catalase. Prompted by the reports that aminoguanidine also inhibits aldose reductase (AR)... |
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Synthesis of condensed pyrimidines and their evaluation for anti-inflammatory and analgesic activities. Sondhi SM, et al.
Indian J. Chem. B 47(1) , 136, (2008)
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Synthesis of biologically active novel bis Schiff bases, bis hydrazone and bis guanidine derivatives. Sondhi SM, et al.
Indian J. Chem. B 48(8) , 1128, (2009)
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