1,6-Dihydroxynaphthalene

1,6-Dihydroxynaphthalene Structure
1,6-Dihydroxynaphthalene structure
Common Name 1,6-Dihydroxynaphthalene
CAS Number 575-44-0 Molecular Weight 160.169
Density 1.3±0.1 g/cm3 Boiling Point 375.4±15.0 °C at 760 mmHg
Molecular Formula C10H8O2 Melting Point 130-133 °C(lit.)
MSDS Chinese USA Flash Point 193.5±15.0 °C
Symbol GHS07
GHS07
Signal Word Warning

Genome-based discovery of a novel membrane-bound 1,6-dihydroxyphenazine prenyltransferase from a marine actinomycete.

PLoS ONE 9(6) , e99122, (2014)

Recently, novel prenylated derivatives of 1,6-dihydroxyphenazine have been isolated from the marine sponge-associated Streptomyces sp. SpC080624SC-11. Genome sequencing of this strain now revealed a gene cluster containing all genes necessary for the synthesi...

Selective antiproliferative activity of hydroxynaphthyl-beta-D-xylosides.

J. Med. Chem. 49 , 1932-8, (2006)

The antiproliferative activity of the 14 isomeric monoxylosylated dihydroxynaphthalenes has been tested in vitro toward normal HFL-1 and 3T3 A31 cells as well as transformed T24 and 3T3 SV40 cells. The antiproliferative effect toward HFL-1 cells was correlate...

Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities.

Bioorg. Med. Chem. 16 , 8117-26, (2008)

NphB is a soluble prenyltransferase from Streptomyces sp. strain CL190 that attaches a geranyl group to a 1,3,6,8-tetrahydroxynaphthalene-derived polyketide during the biosynthesis of anti-oxidant naphterpin. Here we report multiple chemoenzymatic syntheses o...