Trapidil
Trapidil structure
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Common Name | Trapidil | ||
|---|---|---|---|---|
| CAS Number | 15421-84-8 | Molecular Weight | 205.260 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H15N5 | Melting Point | 98-99.4° (Pfeifer); 102-104° from heptane (Tenor) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Protective effects of trapidil in ischemia-reperfusion injury due to testicular torsion and detorsion: an experimental study.
Int. J. Urol. 13(5) , 601-5, (2006) We aimed to detect the preventive effects of trapidil in ischemia-reperfusion (IR) injury due to testicular torsion and detorsion.Forty prepubertal albino rats were used. In the IR group, torsion was created by rotating the left testis over 2 h, and detorsion... |
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Effects of trapidil on renal ischemia-reperfusion injury.
J. Pediatr. Surg. 41(10) , 1686-93, (2006) There is increasing evidence to suggest that reactive oxygen and nitrogen species play a role in the pathogenesis of renal ischemia-reperfusion (I/R) injury. This study was designed to determine the possible protective effects of trapidil treatment against ox... |
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Clinical evidence for Japanese population based on prospective studies—Linking clinical trials and clinical practice
J. Cardiol. 54(2) , 171-82, (2009) “Evidence-based medicine (EBM)” implies effective and high quality practice for patients based on well-grounded medical science. The success of clinical trials in Japan is essential to build original evidence specific for Japanese patients. Based on this conc... |
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Optical coherence tomography in ST-elevation myocardial infarction treated with novel drug-eluting stent: preprocedural, postimplant and 2-month follow-up findings.
J. Cardiovasc. Med. (Hagerstown.) 12(1) , 55-8, (2011) The use of drug-eluting stents (DES) allowed the reduction in the need for repeat revascularization. At the culprit site in acute myocardial infarction patients treated with first-generation DES, the interaction between the eluted drug and the underlying necr... |
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Protective effect of trapidil and l-arginine against renal and hepatic toxicity induced by cyclosporine in rats.
Ren. Fail. 32(8) , 959-68, (2010) Cyclosporine A (CsA) leads to renal and liver injury, production of free radicals and nitric oxide (NO) deficiency. This study investigates the possible protective effects of trapidil and L-arginine against CsA-induced tissue injury.Forty adult male Wistar ra... |
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Rationale and study design of the OISTER trial: optical coherence tomography evaluation of stent struts re-endothelialization in patients with non-ST-elevation acute coronary syndromes--a comparison of the intrEpide tRapidil eluting stent vs. taxus drug-eluting stent implantation.
J. Cardiovasc. Med. (Hagerstown.) 11(7) , 536-43, (2010) Drug-eluting stents (DES) have been designed to prevent restenosis, but long-term clinical outcome may be offset by an increased risk of stent thrombosis, which is associated with suboptimal stent implantation or delayed re-endothelialization. DES implantatio... |
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Trapidil decreases the aggregation of platelets from heart transplant recipients ex vivo.
Transplant. Proc. 38(5) , 1523-5, (2006) Heart transplant recipients show platelet hyperaggregability, which may be related to the incidence of graft vasculopathy. We investigated whether trapidil can inhibit the aggregation of platelets from these patients. Platelet count, mean platelet volume (MPV... |
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Effects of the antianginal drug trapidil on atrioventricular conduction disturbances during acute myocardial ischemia.
Int. Heart J. 53(3) , 187-92, (2012) Adenosine and related compounds have been shown to produce atrioventricular (AV) conduction block during acute myocardial ischemia. We investigated the effects of the antianginal drug trapidil, which has been shown to inhibit phosphodiesterase, on AV conducti... |
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Effect of locally applied trapidil on norepinephrine- and dinoprost-evoked hand vein constriction in healthy men.
Int. J. Clin. Pharmacol. Ther. 45(1) , 10-5, (2007) In this study the effect of locally administered trapidil on human hand veins was examined.10 healthy male volunteers aged 20 - 30 years were included.The dorsal hand vein compliance technique was used. In a crossover design the influence of locally infused t... |
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Influence of systemically given placebo, trapidil and isosorbide dinitrate on norepinephrine-evoked hand vein constriction in healthy subjects.
Arzneimittelforschung 57(2) , 81-6, (2007) Since trapidil (CAS 15421-84-8) is able to dilate human hand veins after local intravenous administration, four studies were carried out in healthy male volunteers using the dorsal hand vein compliance technique to test the influence of common systemic single... |