4-AMINOPYRIDINE
4-AMINOPYRIDINE structure
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Common Name | 4-AMINOPYRIDINE | ||
|---|---|---|---|---|
| CAS Number | 504-24-5 | Molecular Weight | 94.115 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 192.7±40.0 °C at 760 mmHg | |
| Molecular Formula | C5H6N2 | Melting Point | 157 °C | |
| MSDS | Chinese USA | Flash Point | 70.3±27.3 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Ion channel expression in the developing enteric nervous system.
PLoS ONE 10(3) , e0123436, (2015) The enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expression of ion channels by ENCCs in embryonic mice was investigated using a PCR-based array, RT-PCR and immunohistochemistry. Many ... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Vasorelaxant activities of Danhong injection and their differential effects on the rat abdominal aorta and mesenteric artery.
J. Cardiovasc. Pharmacol. 65(1) , 62-71, (2015) Previous studies have found that Danhong injection (DHI), an extensively used herbal extract preparation in China, might be a powerful vasodilator. The aims of this study were to determine the vascular activity of DHI and its effects on arteries of different ... |
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The GPR55 agonist lysophosphatidylinositol relaxes rat mesenteric resistance artery and induces Ca(2+) release in rat mesenteric artery endothelial cells.
Br. J. Pharmacol. 172 , 3043-57, (2015) Lysophosphatidylinositol (LPI), a lipid signalling molecule, activates GPR55 and elevates intracellular Ca(2+). Here, we examine the actions of LPI in the rat resistance mesenteric artery and Ca(2+) responses in endothelial cells isolated from the artery.Vasc... |
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Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion.
Nat. Commun. 5 , 5423, (2014) Synaptic adhesion molecules orchestrate synaptogenesis. The presynaptic leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) regulate synapse development by interacting with postsynaptic Slit- and Trk-like family proteins (Slitr... |
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Effects of moderate static magnetic fields on the voltage-gated sodium and calcium channel currents in trigeminal ganglion neurons.
Electromagn. Biol. Med. 34 , 285-92, (2015) To study the effects of static magnetic fields (SMF) on the electrophysiological properties of voltage-gated sodium and calcium channels on trigeminal ganglion (TRG) neurons.Acutely dissociated TRG neurons of neonatal SD rats were exposed to 125-mT and 12.5-m... |
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Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
J. Neurosci. 35(14) , 5664-79, (2015) The Ca(2+) channelopathies caused by mutations of the CACNA1A gene that encodes the pore-forming subunit of the human Cav2.1 (P/Q-type) voltage-gated Ca(2+) channel include episodic ataxia type 2 (EA2). Although, in EA2 the emphasis has been on cerebellar dys... |
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The role of action potentials in determining neuron-type-specific responses to nitric oxide.
Dev. Neurobiol. 75(5) , 435-51, (2015) The electrical activity in developing and mature neurons determines the intracellular calcium concentration ([Ca(2+)]i), which in turn is translated into biochemical activities through various signaling cascades. Electrical activity is under control of neurom... |
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Effects of new class III antiarrhythmic drug niferidil on electrical activity in murine ventricular myocardium and their ionic mechanisms.
Naunyn Schmiedebergs Arch. Pharmacol. 388 , 1105-12, (2015) A new class III antiarrhythmic drug niferidil has been recently introduced as a highly effective therapy cure for cases of persistent atrial fibrillation, but ionic mechanisms of its action are still unknown. Effects of niferidil on action potential (AP) wave... |
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Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system.
Nat. Commun. 6 , 6761, (2015) How the brain's antioxidant defenses adapt to changing demand is incompletely understood. Here we show that synaptic activity is coupled, via the NMDA receptor (NMDAR), to control of the glutathione antioxidant system. This tunes antioxidant capacity to refle... |