1,5-Difluoro-2,4-dinitrobenzene
1,5-Difluoro-2,4-dinitrobenzene structure
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Common Name | 1,5-Difluoro-2,4-dinitrobenzene | ||
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| CAS Number | 327-92-4 | Molecular Weight | 204.088 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 306.8±37.0 °C at 760 mmHg | |
| Molecular Formula | C6H2F2N2O4 | Melting Point | 72-74 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 139.4±26.5 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Synthesis of variants of Marfey's reagent having d-amino acids as chiral auxiliaries and liquid-chromatographic enantioseparation of (RS)-Mexiletine in spiked plasma: assessment and comparison with L-amino acid analogs.
J. Chromatogr. A. 1379 , 43-50, (2015) Five d-amino acids have been used for the first time to synthesize chiral derivatizing reagents (as variants of Marfey's reagent) by nucleophilic displacement of one of the fluorine atoms in 1,5-difluoro-2,4-dinitrobenzene as against the literature reports on... |
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The quaternary geometry of transcription termination factor rho: assignment by chemical cross-linking.
J. Mol. Biol. 269(4) , 514-28, (1997) Transcription termination factor rho from Escherichia coli is a ring-shaped homohexamer of 419 amino acid subunits and catalyzes an ATP-dependent release of nascent RNA transcripts. Previous chemical cross-linking studies suggested that the rho hexamer might ... |
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Cross-linking protein glutathionylation mediated by O2-arylated bis-diazeniumdiolate "Double JS-K".
Chem. Res. Toxicol. 25(12) , 2670-7, (2012) Attachment of glutathione (GSH) to cysteine residues in proteins (S-glutathionylation) is a reversible post-translational modification that can profoundly alter protein structure and function. Often serving in a protective role, for example, by temporarily sa... |
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Double domain swapping in bovine seminal RNase: formation of distinct N- and C-swapped tetramers and multimers with increasing biological activities.
PLoS ONE 7(10) , e46804, (2012) Bovine seminal (BS) RNase, the unique natively dimeric member of the RNase super-family, represents a special case not only for its additional biological actions but also for the singular features of 3D domain swapping. The native enzyme is indeed a mixture o... |
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Physicochemical changes in phosphorylase kinase induced by its cationic activator Mg(2+).
Protein Sci. 22(4) , 444-54, (2013) For over four decades free Mg(2+) ions, that is, those in excess of MgATP, have been reported to affect a wide variety of properties of phosphorylase kinase (PhK), including its affinity for other molecules, proteolysis, chemical crosslinking, phosphorylation... |
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Structure and location of the regulatory β subunits in the (αβγδ)4 phosphorylase kinase complex.
J. Biol. Chem. 287(44) , 36651-61, (2012) Phosphorylase kinase (PhK) is a hexadecameric (αβγδ)(4) complex that regulates glycogenolysis in skeletal muscle. Activity of the catalytic γ subunit is regulated by allosteric activators targeting the regulatory α, β, and δ subunits. Three-dimensional EM rec... |
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Scaffold-directed and traceless synthesis of tricyclic quinoxalinone imidazoles under microwave irradiation: for SCS-09 special issue-combinatorial approaches to drug discovery.
Mol. Divers. 15(1) , 101-7, (2011) Traceless synthesis of 2-aminoimidazoquinoxalinones has been performed on soluble polymer support under open-vessel microwave dielectric heating. The reaction progression is monitored directly by the conventional proton NMR which indicated no release of the s... |
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Oligomerization of ribonuclease A: two novel three-dimensional domain-swapped tetramers.
J. Biol. Chem. 279(35) , 36670-9, (2004) By lyophilization from 40% acetic acid solutions, bovine ribonuclease A forms several types of three-dimensional domain-swapped oligomers: dimers, trimers, tetramers, and higher order multimers. Each oligomeric species comprehends at least two conformers: one... |
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Rigid tetranitroresorcinarenes.
Org. Lett. 4(9) , 1555-8, (2002) [reaction: see text]. o-alkylation of C2V-symmetrical resorcinarene tetraesters 2 with 2 equiv of 1,3-difluoro-4,6-dinitrobenzene readily affords conformationally rigid octanitro resorcinarene 3, which is a potential scaffold for the design of supramolecular ... |
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CD23/Fc epsilon RII and its soluble fragments can form oligomers on the cell surface and in solution.
Immunology 84(2) , 202-6, (1995) Human CD23 (also known as Fc epsilon RII) is a 45,000 MW glycoprotein with homology to C-type animal lectins. It is involved in B-cell differentiation and IgE regulation, and is naturally cleaved to give soluble products of 37,000, 33,000, 29,000, 25,000 and ... |