(-)-isoproterenol hydrochloride
(-)-isoproterenol hydrochloride structure
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Common Name | (-)-isoproterenol hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 5984-95-2 | Molecular Weight | 247.71900 | |
| Density | N/A | Boiling Point | 441.5ºC at 760 mmHg | |
| Molecular Formula | C11H18ClNO3 | Melting Point | 175ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 220.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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β-adrenergic receptor-dependent alterations in murine cardiac transcript expression are differentially regulated by gefitinib in vivo.
PLoS ONE 9(6) , e99195, (2014) β-adrenergic receptor (βAR)-mediated transactivation of epidermal growth factor receptor (EGFR) has been shown to promote cardioprotection in a mouse model of heart failure and we recently showed that this mechanism leads to enhanced cell survival in part via... |
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Thermogenic activity of UCP1 in human white fat-derived beige adipocytes.
Mol. Endocrinol. 29(1) , 130-9, (2014) Heat-producing beige/brite (brown-in-white) adipocytes in white adipose tissue have the potential to suppress metabolic disease in mice and hold great promise for the treatment of obesity and type 2 diabetes in humans. Here, we demonstrate that human adipose-... |
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Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4.
Br. J. Pharmacol. 171(23) , 5361-75, (2014) This study examined the role of the main vascular cAMP-hydrolysing phosphodiesterases (cAMP-PDE) in the regulation of basal vascular tone and relaxation of rat aorta mediated by β-adrenoceptors, following heart failure (HF).Twenty-two weeks after proximal aor... |
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Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics.
Pharmacol. Res. 105 , 13-21, (2016) G protein-coupled receptors (GPCRs) are essential membrane proteins that facilitate cell-to-cell communication and co-ordinate physiological processes. At least 30 human GPCRs contain a Type I PSD-95/DLG/Zo-1 (PDZ) ligand in their distal C-terminal domain; th... |
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Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction.
Respir. Res. 6 , 85, (2005) In addition to their proliferative and differentiating effects, several growth factors are capable of inducing a sustained airway smooth muscle (ASM) contraction. These contractile effects were previously found to be dependent on Rho-kinase and have also been... |
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Effects of beta3-adrenergic receptor activation on rat urinary bladder hyperactivity induced by ovariectomy.
J. Pharmacol. Exp. Ther. 330 , 704-17, (2009) Voiding dysfunctions, including increased voiding frequency, urgency, or incontinence, are prevalent in the postmenopausal population. Beta(3)-adrenergic receptor (beta(3)AR) agonists, which relax bladder smooth muscle, are being developed to treat these cond... |
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Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma.
Respir. Res. 7 , 6, (2006) Using guinea pig tracheal preparations, we have recently shown that endogenous arginase activity attenuates inhibitory nonadrenergic noncholinergic (iNANC) nerve-mediated airway smooth muscle relaxation by reducing nitric oxide (NO) production--due to competi... |
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Arginase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxation.
Respir. Res. 6 , 23, (2005) Recent evidence suggests that endogenous arginase activity potentiates airway responsiveness to methacholine by attenuation of agonist-induced nitric oxide (NO) production, presumably by competition with epithelial constitutive NO synthase for the common subs... |
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β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.
PLoS ONE 7 , e47826, (2012) We investigated the role of cyclic nucleotide phosphodiesterases (PDEs) in the spatiotemporal control of intracellular cAMP concentrations in rat aortic smooth muscle cells (RASMCs).The rank order of PDE families contributing to global cAMP-PDE activity was P... |
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BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo.
Am. J. Physiol. Heart Circ. Physiol. 307(9) , H1327-38, (2014) Large-conductance Ca(2+)- and voltage-activated K(+) (BK) channels play prominent roles in shaping muscle and neuronal excitability. In the cardiovascular system, BK channels promote vascular relaxation and protect against ischemic injury. Recently, inhibitio... |