4-IPP
4-IPP structure
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Common Name | 4-IPP | ||
|---|---|---|---|---|
| CAS Number | 41270-96-6 | Molecular Weight | 282.08000 | |
| Density | 1.728±0.06 g/cm3 | Boiling Point | 380.2±30.0 °C | |
| Molecular Formula | C10H7IN2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Podocyte injury-driven lipid peroxidation accelerates the infiltration of glomerular foam cells in focal segmental glomerulosclerosis.
Am. J. Pathol. 185 , 2118-31, (2015) Intracapillary foam cell infiltration with podocyte alterations is a characteristic pathology of focal segmental glomerulosclerosis (FSGS). We investigated the possible role of podocyte injury in glomerular macrophage and foam cell infiltration in a podocyte-... |
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Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer.
BMC Cancer 15 , 843, (2015) Poor prognosis in gallbladder cancer is due to late presentation of the disease, lack of reliable biomarkers for early diagnosis and limited targeted therapies. Early diagnostic markers and novel therapeutic targets can significantly improve clinical manageme... |
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Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses.
PLoS ONE 8 , e78250, (2013) The diagnosis and treatment of soft tissue sarcomas (STSs) has been particularly difficult, because STSs are a group of highly heterogeneous tumors in terms of histopathology, histological grade, and primary site. Recent advances in genome technologies have p... |
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PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma.
Oncotarget 6(2) , 846-61, (2015) Pyruvate kinase M2 (PKM2) is a member of the pyruvate kinase family. Recent work has defined the "non-metabolic" functions of PKM2. However, the role of PKM2 in HCC remains unclear. To investigate the role of PKM2 in tumor growth, invasion and the prognosis o... |
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Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.
FASEB J. 28(11) , 4961-71, (2014) We report a new inflammatory activity for extracellular d-dopachrome tautomerase (D-DT), the recruitment of neutrophils to the lung on D-DT intratracheal installation of C57BL/6J mice with an EC50 of 5.6 μg. We also find that D-DT and macrophage migration inh... |
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MIF Is Necessary for Late-Stage Melanoma Patient MDSC Immune Suppression and Differentiation.
Cancer. Immunol. Res. 4 , 101-12, (2016) Highly aggressive cancers "entrain" innate and adaptive immune cells to suppress antitumor lymphocyte responses. Circulating myeloid-derived suppressor cells (MDSC) constitute the bulk of monocytic immunosuppressive activity in late-stage melanoma patients. P... |
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4-IPP, a selective MIF inhibitor, causes mitotic catastrophe in thyroid carcinomas.
Endocr. Relat. Cancer 22 , 759-75, (2015) Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is over-expressed in several human neoplastic cells. When MIF binds its receptor (CD74) and co-receptor (CD44), it initiates signaling cascades that orchestrate cell proliferatio... |