1-Methyl-2-nitrosobenzene
1-Methyl-2-nitrosobenzene structure
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Common Name | 1-Methyl-2-nitrosobenzene | ||
|---|---|---|---|---|
| CAS Number | 611-23-4 | Molecular Weight | 121.137 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 199.9±19.0 °C at 760 mmHg | |
| Molecular Formula | C7H7NO | Melting Point | 72-75 °C(lit.) | |
| MSDS | USA | Flash Point | 74.7±26.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes.
Arch. Biochem. Biophys. 436(2) , 265-75, (2005) The inactivation of cytochrome P450 enzymes by cyclopropylamines has been attributed to a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring leading to covalent modification of the enzyme. Herein, we r... |
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Distinct mechanisms of oxidative DNA damage by two metabolites of carcinogenic o-toluidine.
Arch. Biochem. Biophys. 372(1) , 97-106, (1999) Mechanisms of DNA damage by metabolites of carcinogenic o-toluidine in the presence of metals were investigated by the DNA sequencing technique using (32)P-labeled human DNA fragments. 4-Amino-3-methylphenol, a major metabolite, caused DNA damage in the prese... |
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Comparative carcinogenicity of o-toluidine hydrochloride and o-nitrosotoluene in F-344 rats.
Cancer Lett. 16(1) , 103-8, (1982) o-Toluidine hydrochloride and one of its metabolites, o-nitrosotoluene, were administered in the diet (0.028 mol/kg diet) to 2 groups of 30 male F-344 rats for 72 weeks. o-Nitrosotoluene induced significantly more tumors of the bladder (16/30 rats) and liver ... |
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Estimation of N-hydroxy-o-toluidine, a urinary metabolite of o-toluidine and o-nitrosotoluene, by high performance liquid chromatography with electrochemical detection.
Carcinogenesis 4(10) , 1275-9, (1983) High-performance liquid chromatography with electrochemical detection, a highly sensitive and specific method, was used to determine N-hydroxy-o-toluidine and o-toluidine in the urines of male F344 rats after the administration of 0.82 mmol/kg of o-toluidine ... |
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Bioassay for carcinogenicity of 3,2'-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters.
Cancer Lett. 20(3) , 349-54, (1983) 3,2'-Dimethyl-4-aminobiphenyl and 3,2'-dimethyl-4-nitrosobiphenyl were administered by subcutaneous injection in peanut oil to 2 groups of 15 male and 15 female Syrian golden hamsters. The total dose of each compound was 5.6 mmol/kg. In the group treated with... |