Destruxin A
Destruxin A structure
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Common Name | Destruxin A | ||
|---|---|---|---|---|
| CAS Number | 6686-70-0 | Molecular Weight | 577.71300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H47N5O7 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Concurrence of losing a chromosome and the ability to produce destruxins in a mutant of Metarhizium anisopliae.
FEMS Microbiol. Lett. 226(2) , 373-8, (2003) In a previous study, a spontaneous subtilisin pr1A and pr1B gene-deficient mutant of the entomopathogenic fungus Metarhizium anisopliae strain V275 has been identified [Wang, C.-S. et al. (2002) FEMS Microbiol. Lett. 213, 251-255]. The insecticidal metabolite... |
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Synthesis and biological evaluation of destruxin A and related analogs.
J. Pept. Res. 58(1) , 1-11, (2001) This report describes the development of an efficient solid-phase synthesis protocol and adaptation of reported solution phase procedures for the synthesis of the cyclic depsihexapeptide destruxin A and related analogs. The solid-phase method described is bas... |
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Non-cyclic AMP-dependent, positive inotropic cyclodepsipeptides with negative chronotropy.
J. Pharmacol. Exp. Ther. 290(3) , 1006-12, (1999) The effects of natural cyclodepsipeptides (CDPs) on isolated rat cardiac tissue preparations were examined in vitro. Destruxin A, destruxin B (DB), roseotoxin B (RB), and roseocardin (RC), a novel CDP, each caused a concentration-dependent increase in the con... |
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Production of cyclodepsipeptides destruxin A and B from Metarhizium anisopliae.
Biotechnol. Prog. 16(6) , 993-9, (2000) Maltose and peptone were the best carbon and nitrogen sources for the production of destruxins from Metarhizium anisopliae. With the addition of 0.1% (w/v) beta-alanine to the basal medium, the yields of cyclodepsipeptides DA and DB were 7.2 and 279 mg/L, res... |
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Toxic effect of destruxin A on abnormal wing disc-like (SLAWD) in Spodoptera litura fabricius (Lepidoptera: Noctuidae).
PLoS ONE 8(2) , e57213, (2013) Destruxin A (DA) is a microbial insecticide with potent bioactivity against Spodoptera litura larvae. A previous proteomic analysis of S. litura (SL-1) cells exposed to DA showed the abnormal expression of wing disc-like protein of S. litura (SLAWD). To furth... |
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The destruxins: synthesis, biosynthesis, biotransformation, and biological activity.
Phytochemistry 59(6) , 579-96, (2002) Destruxins, secondary metabolites first reported in 1961, are cyclic hexadepsipeptides composed of an alpha-hydroxy acid and five amino acid residues. The name "destruxin" is derived from "destructor" from the species Oospora destructor, the entomopathogenic ... |
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Toxicity and differential protein analysis following destruxin A treatment of Spodoptera litura (Lepidoptera: Noctuidae) SL-1 cells.
Toxicon 58(4) , 327-35, (2011) The cytotoxicity of a destruxin A (DA) treatment of Spodoptera litura SL-1 cells was investigated. An MTT assay showed that DA was highly toxic to SL-1 cells in a concentration- and time-dependent manner. The IC(50) values of DA, after 24 h and 48 h of treatm... |
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An investigation of the ionophoric characteristics of destruxin A.
Arch. Biochem. Biophys. 405(1) , 73-77, (2002) Destruxin A, a cyclohexadepsipeptide related to the enniatins and beauvericin, exhibits ionophoric properties. Calcium ion mobilization across liposomal membrane barriers, for example, has been demonstrated using the calcium ion-sensitive dyes Arsenazo III an... |
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Roseocardin, a novel cardiotonic cyclodepsipeptide from Trichothecium roseum TT103.
J. Antibiot. 50(12) , 1007-13, (1997) A new cyclodepsipeptide, designated roseocardin, was isolated from the culture broth of Trichothecium roseum TT103. Roseotoxin B and destruxins A and B were also isolated during the same procedure. The structure of roseocardin was determined by EI-MS, NMR and... |
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Toxicity testing of destruxins and crude extracts from the insect-pathogenic fungus Metarhizium anisopliae.
FEMS Microbiol. Lett. 251(1) , 23-8, (2005) Increasing sensitivity towards secondary metabolites from fungal biological control agents (BCAs) has prompted the toxicological risk assessment of metabolites produced by the insect pathogenic fungus Metarhizium anisopliae. Viability studies on one human and... |