3-Chloro-4-fluoroaniline
3-Chloro-4-fluoroaniline structure
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Common Name | 3-Chloro-4-fluoroaniline | ||
|---|---|---|---|---|
| CAS Number | 367-21-5 | Molecular Weight | 145.56 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 227.5±0.0 °C at 760 mmHg | |
| Molecular Formula | C6H5ClFN | Melting Point | 42-44 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 99.4±21.8 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Reductive deamination as a new step in the anaerobic microbial degradation of halogenated anilines.
FEMS Microbiol. Lett. 209(2) , 307-12, (2002) In this paper we report the isolation and characterization of an anaerobic enrichment culture as well as of a Rhodococcus sp. strain 2 capable of degrading 3,4-dihaloanilines under nitrate reducing conditions. Using mass spectrometry several of the intermedia... |
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An improved analytical method, based on HPLC with electrochemical detection, for monitoring exposure to 3-chloro-4-fluoroaniline.
J. Anal. Toxicol. 12(6) , 330-3, (1988) An HPLC method for monitoring exposure of workers to 3-chloro-4-fluoroaniline (CFA) is described. It is based on the detection of a major urinary metabolite, 2-amino-4-chloro-5-fluorophenyl sulphate, and is superior to the previously adopted GC method. The li... |
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Biological monitoring of exposure to 3-chloro-4-fluoroaniline by determination of a urinary metabolite and a hemoglobin adduct.
Environ. Health Perspect. 102 Suppl 6 , 23-5, (1994) In two studies, involving 75 and 72 workers, potential exposure to 3-chloro-4-fluoroaniline (CFA) was biologically monitored by determination of its main urinary metabolite 2-amino-4-chloro-5-fluorophenol sulfate (CFA-S). As this method only allows the detect... |
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Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]-radiolabelling, 19F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR.
Xenobiotica 36(1) , 59-77, (2006) The metabolic fate of 3-chloro-4-fluoroaniline was investigated in rat following intraperitoneal (i.p.) administration at 5 and 50 mg kg(-1) using a combination of HPLC-MS, HPLC-MS/MS, (19)F-NMR spectroscopy, HPLC-NMR spectroscopy and high-pressure liquid chr... |
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The metabolism of 3-chloro-4-fluoro-aniline in dog and rat.
Xenobiotica 10(2) , 135-44, (1980) 1. 3-Chloro-4-fluorol[14C]aniline, orally administered to a female dog (0.135 mg/kg), was eliminated in the urine as 2-amino-4-chloro-5-fluorophenyl sulphate (83% in 48 h). 2. When 3-chloro-4-fluoro[14C]aniline was administered orally to male rats (ca 2.3 mg/... |