etoricoxib
etoricoxib structure
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Common Name | etoricoxib | ||
|---|---|---|---|---|
| CAS Number | 202409-33-4 | Molecular Weight | 358.842 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 510.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H15ClN2O2S | Melting Point | 134-135°C | |
| MSDS | Chinese USA | Flash Point | 262.2±30.1 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Analgesic activity of Eugenia jambolana leave constituent: a dikaempferol rhamnopyranoside from ethyl acetate soluble fraction.
Pharm. Biol. 52(8) , 1069-78, (2014) Eugenia jambolana Lam. (Myrtaceae) is a medicinal plant used in folk medicine for the treatment of diabetes, inflammation, and pain.We investigated the antinociceptive effect of kaempferol-7-O-α-l-rhamnopyranoside]- 4'-O-4'-[kaempferol-7-O-α-l-rhamnopyranosid... |
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Downregulation of NF-κB and PCNA in the regulatory pathways of apoptosis by cyclooxygenase-2 inhibitors in experimental lung cancer.
Mol. Cell Biochem. 369(1-2) , 75-86, (2012) Non-steroidal anti-inflammatory drugs (NSAIDs) are emerging as novel chemopreventive agents against a variety of cancers owing to their capability in blocking the tumor development by cellular proliferation, angiogenesis and by promoting apoptosis. The presen... |
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Angiostatic role of the selective cyclooxygenase-2 inhibitor etoricoxib (MK0663) in experimental lung cancer.
Biomed. Pharmacother. 66(6) , 474-83, (2012) Lung cancer was induced in Sprague-Dawley rats by a single intra-tracheal instillation of 9,10-dimethybenz(a)anthracene (DMBA) and evaluated the anti-angiogenic action of etoricoxib, which is a selective cyclooxygenase-2 (COX-2) inhibitor. The animals were di... |
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Evaluation of a single preoperative dose of etoricoxib for postoperative pain relief in therapeutic knee arthroscopy: a randomized trial.
Acta Orthop. 83(6) , 642-7, (2012) BACKGROUND AND PURPOSE Analgesics can have undesirable effects. We assessed whether a single preoperative dose of 120 mg etoricoxib reduces the need for additional opioids after therapeutic arthroscopic knee surgery. METHODS A double-blind, placebo-controlled... |
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Nuclear factor kappa B: a pro-inflammatory, transcription factor-mediated signalling pathway in lung carcinogenesis and its inhibition by nonsteroidal anti-inflammatory drugs.
J. Environ. Pathol. Toxicol. Oncol. 31(1) , 27-37, (2012) 9,10-Dimethyl benz(a)anthracene (DMBA), when injected intratracheally once at a dose of 20 mg/kg body weight, is found to induce lung cancer in rats. Two nonsteroidal anti-inflammatory drugs (NSAIDs), indomethacin and etoricoxib, are given orally daily as che... |
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Etoricoxib: a highly selective COX-2 inhibitor.
Ann. Pharmacother. 39(5) , 854-62, (2005) To review the available literature evaluating the pharmacology, pharmacokinetics, clinical efficacy, and adverse effects of etoricoxib, a highly selective cyclooxygenase-2 (COX-2) inhibitor that is not currently approved for use in the US.Literature retrieval... |
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Etoricoxib.
Drugs Today (Barc) 40(5) , 395-414, (2004) Etoricoxib (Arcoxia, Merck & Co., Inc.) is a selective inhibitor of cyclooxygenase-2 (COX-2), an enzyme involved in pain and inflammation. It is a member of the COX-2-selective (coxib) class of nonsteroidal antiinflammatory drugs (NSAIDs). Extensive clinical ... |
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Role of cytokines in experimentally induced lung cancer and chemoprevention by COX-2 selective inhibitor, etoricoxib.
Mol. Cell Biochem. 372(1-2) , 101-12, (2013) This study explored the role of pro- and anti-inflammatory cytokines in dimethyl benz(a)anthracene (DMBA)-induced lung cancer and its subsequent correction with a COX-2 inhibitory NSAID, etoricoxib. A single dose of DMBA (20 mg/kg body weight) in 0.9 % NaCl a... |
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The first example of a patient with etoricoxib-induced immune hemolytic anemia.
Transfusion 53(5) , 1033-6, (2013) Etoricoxib, a selective inhibitor of cyclooxygenase 2, is increasingly used in pain relief. Here, we report the first case of etoricoxib-induced immune hemolytic anemia.An 84-year-old male patient developed anemia 1 week after treatment with etoricoxib. There... |
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Tolerability to etoricoxib in patients with aspirin-exacerbated respiratory disease.
J. Investig. Allergol. Clin. Immunol. 23(4) , 275-80, (2013) The use of selective cyclooxygenase (COX) 2 inhibitors as an alternative to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has been suggested for patients with aspirin-exacerbated respiratory disease (AERD).To evaluate tolerability to etorico... |