Mazindol
Mazindol structure
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Common Name | Mazindol | ||
|---|---|---|---|---|
| CAS Number | 22232-71-9 | Molecular Weight | 284.74000 | |
| Density | 1.39 | Boiling Point | 454.9ºC at 760 mmHg | |
| Molecular Formula | C16H13ClN2O | Melting Point | 215-217ºC | |
| MSDS | Chinese USA | Flash Point | 228.9ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Development and validation of an LC-MS/MS method for the simultaneous analysis of 28 specific narcotic adulterants used in dietary supplements.
Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 1029-39, (2015) The purpose of this study was to develop a method to analyse the concentration of multiple illegal narcotics present in dietary supplements. To this end, we established and optimised a procedure using LC-MS/MS simultaneously to analyse 28 narcotic compounds i... |
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Plasma membrane monoamine transporters: structure, regulation and function.
Nat. Rev. Neurosci. 4 , 13-25, (2003)
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Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6-hydroxydopamine lesion.
Neuroscience 154(3) , 1088-99, (2008) Striatal projection neurons use GABA as their neurotransmitter and express the rate-limiting synthesizing enzyme glutamic acid decarboxylase (GAD) and the vesicular GABA transporter vGAT. The chronic systemic administration of an agonist of dopamine D1/D5-pre... |
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Study on detection of drugs in slimming health foods using GC-MS/MS.
Shokuhin Eiseigaku Zasshi 52(6) , 363-9, (2011) The determination of five drugs, fenfluramine (FEN), N-nitrosofenfluramine (NFE), sibutramine (SIB), mazindol (MAZ) and phenolphthalein (PHP), was studied in slimming health foods using GC-MS/MS. These drugs have been detected at high rates, especially in sli... |
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Raloxifene activates G protein-coupled estrogen receptor 1/Akt signaling to protect dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice.
Neurobiol. Aging 35(10) , 2347-56, (2014) Raloxifene, used in the clinic, is reported to protect brain dopaminergic neurons in mice. Raloxifene was shown to mediate an effect through the G protein-coupled estrogen receptor 1 (GPER1). We investigated if raloxifene neuroprotective effect in 1-methyl-4-... |
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Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature 503(7474) , 141-5, (2013) The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) a... |
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Markers of serotonergic function in the orbitofrontal cortex and dorsal raphé nucleus predict individual variation in spatial-discrimination serial reversal learning.
Neuropsychopharmacology 40 , 1619-30, (2015) Dysfunction of the orbitofrontal cortex (OFC) impairs the ability of individuals to flexibly adapt behavior to changing stimulus-reward (S-R) contingencies. Impaired flexibility also results from interventions that alter serotonin (5-HT) and dopamine (DA) tra... |
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Clinical and basic aspects of an anorexiant, mazindol, as an antiobesity agent in Japan.
Am. J. Clin. Nutr. 55(1 Suppl) , 199S-202S, (1992) The Japanese Mazindol study group investigated the action of an anorexiant, mazindol, and found that it reduced food intake by directly suppressing neurons in the lateral hypothalamus, inhibited gastric acid secretion, increased motor activity, decreased gluc... |
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Pharmacological treatment of obesity.
Arq. Bras. Endocrinol. Metabol. 50(2) , 377-89, (2006) This review offers an overview of physiological agents, current therapeutics, as well as medications, which have been extensively used and those agents not currently available or non-classically considered anti-obesity drugs. As obesity - particularly that of... |
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Obesity.
Clin. Evid. (13) , 707-25, (2005)
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