Nalbuphine Hydrochloride
Nalbuphine Hydrochloride structure
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Common Name | Nalbuphine Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 23277-43-2 | Molecular Weight | 393.90400 | |
| Density | N/A | Boiling Point | 566.6ºC at 760 mmHg | |
| Molecular Formula | C21H28ClNO4 | Melting Point | 230.5ºC | |
| MSDS | Chinese USA | Flash Point | 296.5ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Pharmacokinetics of nalbuphine hydrochloride after intravenous and intramuscular administration to Hispaniolan Amazon parrots (Amazona ventralis).
Am. J. Vet. Res. 72(6) , 741-5, (2011) To assess the pharmacokinetics of nalbuphine HCl after IV and IM administration to Hispaniolan Amazon parrots (Amazona ventralis).8 healthy adult Hispaniolan Amazon parrots of unknown sex.Nalbuphine HCl (12.5 mg/kg) was administered IV and IM to all birds in ... |
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A review of systemic opioids commonly used for labor pain relief.
J. Midwifery Womens. Health 56(3) , 222-39, (2011) Parenteral opioids for pain relief during labor have been the subject of research for many decades. Commonly used systemic opioids provide limited pain relief during labor yet are used extensively for managing labor pain. These opioids share similar pharmacol... |
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Ultrasound guidance characteristics and efficiency of suprazygomatic maxillary nerve blocks in infants: a descriptive prospective study.
Paediatr. Anaesth. 22(9) , 841-6, (2012) Bilateral suprazygomatic maxillary nerve blocks approach improves pain relief after palate surgery. We report the feasibility and efficiency of ultrasound-guided suprazygomatic maxillary nerve blocks in cleft palate repair in children.Twenty-five children sch... |
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Evaluation of topical nalbuphine or oral tramadol as analgesics for corneal pain in dogs: a pilot study.
Vet. Ophthalmol. 14(6) , 358-64, (2011) To evaluate the effectiveness of topical nalbuphine or oral tramadol in the treatment of corneal pain in dogs.Fourteen male Beagle dogs.Dogs were divided into three treatment groups and sedated with dexmedetomidine (5 μ/kg IV). A 4 mm corneal epithelial wound... |
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Pain facilitation brain regions activated by nalbuphine are revealed by pharmacological fMRI.
PLoS ONE 8(1) , e50169, (2013) Nalbuphine, an agonist-antagonist kappa-opioid, produces brief analgesia followed by enhanced pain/hyperalgesia in male postsurgical patients. However, it produces profound analgesia without pain enhancement when co-administration with low dose naloxone. To e... |
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The mu/kappa agonist nalbuphine attenuates sensitization to the behavioral effects of cocaine.
Pharmacol. Biochem. Behav. 104 , 40-6, (2013) Sensitization refers to an increase in sensitivity to a drug and is believed to play a role in the etiology of substance use disorders. The purpose of the present study was to evaluate the ability of the mixed mu/kappa agonist nalbuphine to modulate sensitiza... |
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Validated LC-MS/MS assay for the quantitative determination of nalbuphine in human plasma and its application to a pharmacokinetic study.
Biomed. Chromatogr. 25(12) , 1308-14, (2011) A solid-phase extraction-liquid chromatographic-tandem mass spectrometry method for the determination of nalbuphine concentrations in human plasma has been developed. Samples (1 mL) were extracted using a Strata™-X solid phase extraction cartridges. Chromatog... |
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Analysis of the transport of and cytotoxic effects for nalbuphine solution in corneal cells.
Am. J. Vet. Res. 73(12) , 1987-95, (2012) To assess the in vitro effects of various nalbuphine concentrations on viability and wound healing ability of corneal cells and potential drug transport through the corneal epithelium.Cultured canine and human corneal epithelial cells (CECs) and cultured cani... |
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The impact of parenteral narcotic choice in the development of acute chest syndrome in sickle cell disease.
J. Pediatr. Hematol. Oncol. 33(4) , 255-60, (2011) Acute chest syndrome (ACS) represents a serious morbidity and often fatal complication in patients with sickle cell disease. Painful episodes which require hospitalization are most often treated with opioids, which may then influence the development of ACS. N... |
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A case of severe toxicity during coadministration of vincristine and piperacillin: are drug transporters involved in vincristine hypersensitivity and drug-drug interactions?
J. Pediatr. Hematol. Oncol. 34(8) , e341-3, (2012) Neurotoxicity is frequent with vincristine treatment, but severe autonomic neuropathy is rare. A decreased activity of drug transporters in the presence of an interacting drug may favor such events by increasing systemic or tissue exposure to the drug. We enc... |