Xylazine hydrochloride

Xylazine hydrochloride Structure
Xylazine hydrochloride structure
Common Name Xylazine hydrochloride
CAS Number 23076-35-9 Molecular Weight 256.795
Density 1.15g/cm3 Boiling Point 334.2ºC at 760mmHg
Molecular Formula C12H17ClN2S Melting Point 150-164?C (dec.)
MSDS USA Flash Point 155.9ºC
Symbol GHS06
GHS06
Signal Word Danger

Poly(ADP-Ribose) Polymerase Inhibition Improves Corneal Epithelial Innervation and Wound Healing in Diabetic Rats.

Invest. Ophthalmol. Vis. Sci. 56(3) , 1948-55, (2015)

We evaluated the effect of poly(ADP-ribose) polymerase (PARP) inhibition by using 1,5-isoquinolinediol (ISO) on corneal epithelial innervation in diabetic rats.ISO (3 mg/kg, intraperitoneal) or vehicle was administered to rats with diabetes induced by strepto...

Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling.

PLoS Comput. Biol. 11 , e1004192, (2015)

Signaling pathways are characterized by crosstalk, feedback and feedforward mechanisms giving rise to highly complex and cell-context specific signaling networks. Dissecting the underlying relations is crucial to predict the impact of targeted perturbations. ...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ...

Determination of 15 sedative residues in mutton by rapid resolution liquid chromatography-tandem mass spectrometry.

J. Sci. Food Agric. 95(3) , 598-606, (2015)

The use of xenobiotic compounds in animal husbandry has given rise to consumer anxieties regarding residual risk and food safety. Thus, animal tissues have become main samples for residue analysis and food safety for sedatives. In this study, a rapid resoluti...

Investigation of Overrun-Processed Porous Hyaluronic Acid Carriers in Corneal Endothelial Tissue Engineering.

PLoS ONE 10 , e0136067, (2015)

Hyaluronic acid (HA) is a linear polysaccharide naturally found in the eye and therefore is one of the most promising biomaterials for corneal endothelial regenerative medicine. This study reports, for the first time, the development of overrun-processed poro...

Upregulation of bone morphogenetic protein-1/mammalian tolloid and procollagen C-proteinase enhancer-1 in corneal scarring.

Invest. Ophthalmol. Vis. Sci. 55(10) , 6712-21, (2014)

To characterize the expression of the bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases (collectively called BTPs), which include BMP-1, mammalian tolloid (mTLD), and mammalian tolloid-like 1 (mTLL-1) and 2 (mTLL-2), as well as the associated prot...

Transscleral delivery of Nd: YLF laser at 1,047 nm causes vascular occlusion in experimental pigmented choroidal melanoma.

Retina (Philadelphia, Pa.) 34(4) , 792-800, (2014)

The aims of this study were to determine the scleral attenuation of focused neodymium: yttrium-lanthanum-fluoride laser at 1,047 nm applied transsclerally and whether transscleral delivery can close the vascular supply at the base of experimental choroidal me...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279...

Functional evaluation using multifocal electroretinogram after selective retina therapy with a microsecond-pulsed laser.

Invest. Ophthalmol. Vis. Sci. 56(1) , 122-31, (2015)

To evaluate the changes of retinal function with multifocal electroretinogram (mfERG), and estimate the association between functional and structural changes after selective retina therapy (SRT) with microsecond-pulsed laser in comparison to continuous wave l...

Human placenta-derived adherent cells improve cardiac performance in mice with chronic heart failure.

Stem Cells Transl. Med. 4(3) , 269-75, (2015)

Human placenta-derived adherent cells (PDACs) are a culture-expanded, undifferentiated mesenchymal-like population derived from full-term placental tissue, with immunomodulatory, anti-inflammatory, angiogenic, and neuroprotective properties. PDA-001 (cenplace...