5-(6)-Carboxy-2',7'-dichlorofluorescein
5-(6)-Carboxy-2',7'-dichlorofluorescein structure
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Common Name | 5-(6)-Carboxy-2',7'-dichlorofluorescein | ||
|---|---|---|---|---|
| CAS Number | 111843-78-8 | Molecular Weight | 445.20600 | |
| Density | 1.86g/cm3 | Boiling Point | 732.3ºC at 760mmHg | |
| Molecular Formula | C21H10Cl2O7 | Melting Point | 250ºC | |
| MSDS | Chinese USA | Flash Point | 396.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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alpha-keto-beta-methyl-n-valeric acid diminishes reactive oxygen species and alters endoplasmic reticulum Ca(2+) stores.
Free Radic. Biol. Med. 37 , 1779-1789, (2004) Mitochondrial dysfunction and oxidative stress occur in neurodegenerative diseases. Other results show that bombesin-releasable calcium stores (BRCS) from the endoplasmic reticulum (ER) are exaggerated in fibroblasts from patients with Alzheimer's disease (AD... |
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Homocysteinic acid causes oxidative stress in lymphocytes by potentiating toxic effect of NMDA.
Bull. Exp. Biol. Med. 140(1) , 33-7, (2005) Short-term incubation of lymphocytes with homocysteine or its oxidation product homocysteinic acid increased the formation of reactive oxygen species and cell necrosis (in case of homocysteinic acid). Effective concentration of homocysteine and homocysteinic ... |
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Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.
Drug Metab. Dispos. 40 , 1825-33, (2012) Transporter gene knockout rats are practically advantageous over murine models for pharmacokinetic and excretion studies, but their phenotypic characterization is lacking. At present, relevant aspects of pharmacokinetics, metabolism, distribution, and excreti... |
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A high throughput in vitro mrp2 assay to predict in vivo biliary excretion.
Xenobiotica 42 , 157-163, (2012) Prediction of biliary excretion is a challenge for drug discovery scientists due to the lack of in vitro assays. This study explores the possibility of establishing a simple assay to predict in vivo biliary excretion via the mrp2 transport system. In vitro mr... |
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Impact of probe compound in MRP2 vesicular transport assays.
Eur. J. Pharm. Sci. 46 , 100-105, (2012) MRP2 is an efflux transporter that is expressed mainly in the canalicular membrane of hepatocytes, where it expels polar and ionic compounds into the bile. MRP2 is also present in the apical membrane of enterocytes and epithelial cells of proximal tubules of ... |
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Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug-drug interaction induced by liver metabolites.
Toxicol. Appl. Pharmacol. 263 , 244-250, (2012) We previously reported a quantitative time-lapse imaging (QTLI)-based analysis method to assess drug-drug interactions (DDI) at multidrug resistance-associated protein 2 (Mrp2) in rat sandwich-cultured hepatocyte (SCH) system, utilizing the fluorescent Mrp2 s... |
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Characterization of rhodamine-123, calcein and 5(6)-carboxy-2',7'-dichlorofluorescein (CDCF) export via MRP2 (ABCC2) in MES-SA and A549 cells.
Eur. J. Pharm. Sci. 43 , 359-369, (2011) Based on our initial results on the effects of several ATP-binding cassette (ABC) transporter inhibitors on rhodamine-123 efflux from A549, a human lung carcinoma, and MES-SA, a human uterine sarcoma cell line, the aim of this study was to identify the transp... |
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Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice.
Drug Metab. Dispos. 34(4) , 718-23, (2006) This study characterized the hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein (CDF), a model Abcc2/Mrp2 (canalicular) and Abcc3/Mrp3 (basolateral) substrate, in perfused livers from male C57BL/6 wild-type, Abcg2-/-, and Abcc2-/- mice. ... |
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Development of a fluorescence-based assay for drug interactions with human Multidrug Resistance Related Protein (MRP2; ABCC2) in MDCKII-MRP2 membrane vesicles
Eur. J. Pharm. Biopharm. 75(2) , 284-90, (2010) Purpose To establish a fluorescence-based assay for drug interactions with the ABC-export-protein MRP2 (ABCC2). |
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Modulation of hepatic canalicular or basolateral transport proteins alters hepatobiliary disposition of a model organic anion in the isolated perfused rat liver.
Drug Metab. Dispos. 33(8) , 1238-43, (2005) This study examined the impact of hepatic transport protein modulation on the hepatobiliary disposition of a nonmetabolized probe substrate, 5- (and 6)-carboxy-2',7'dichlorofluorescein (CDF) in rat isolated perfused livers (IPLs). In vivo treatment with modul... |