2-Oxobutyric acid
2-Oxobutyric acid structure
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Common Name | 2-Oxobutyric acid | ||
|---|---|---|---|---|
| CAS Number | 600-18-0 | Molecular Weight | 102.089 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 177.8±0.0 °C at 760 mmHg | |
| Molecular Formula | C4H6O3 | Melting Point | 30-34 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 65.0±15.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Mosquito odorant receptor for DEET and methyl jasmonate.
Proc. Natl. Acad. Sci. U. S. A. 111(46) , 16592-7, (2014) Insect repellents are important prophylactic tools for travelers and populations living in endemic areas of malaria, dengue, encephalitis, and other vector-borne diseases. DEET (N,N-diethyl-3-methylbenzamide) is a 6-decade-old synthetic repellent, which is st... |
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Kinetic resolution of 2-hydroxybutanoate racemic mixtures by NAD-independent L-lactate dehydrogenase.
Bioresour. Technol. 102(7) , 4595-9, (2011) Optically active D-2-hydroxybutanoate is an important building block intermediate for medicines and biodegradable poly(2-hydroxybutanoate). Kinetic resolution of racemic 2-hydroxybutanoate may be a green and desirable alternative for D-2-hydroxybutanoate prod... |
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Transaminase-catalyzed asymmetric synthesis of L-2-aminobutyric acid from achiral reactants.
Biotechnol. Lett. 31 , 1595-1599, (2009) Asymmetric synthesis of an unnatural amino acid was demonstrated by omega-transaminase from Vibrio fluvialis JS17. L-2-Aminobutyric acid was synthesized from 2-oxobutyric acid and benzylamine with an enantiomeric excess higher than 99%. The reaction showed se... |
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Defect in alpha-ketobutyrate metabolism: a new inborn error.
Clin. Chim. Acta 145(2) , 173-82, (1985) A pair of siblings with clinical symptoms of cyclic vomiting and ketoacidosis were found to have a biochemical triad of normoglycemia, ketoacidosis and elevated levels of alpha-hydroxy- and alpha-aminobutyrate in plasma and urine. Methionine loading studies i... |
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Expanding metabolism for total biosynthesis of the nonnatural amino acid L-homoalanine.
Proc. Natl. Acad. Sci. U. S. A. 107(14) , 6234-9, (2010) The dramatic increase in healthcare cost has become a significant burden to the world. Many patients are denied the accessibility of medication because of the high price of drugs. Total biosynthesis of chiral drug intermediates is an environmentally friendly ... |
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Characterization of ACC deaminase gene in Pseudomonas entomophila strain PS-PJH isolated from the rhizosphere soil.
J. Basic Microbiol. 50(2) , 200-5, (2010) The enzyme 1-aminocyclopropane-1-carboxylate (ACC) deaminase cleaves the ethylene precursor ACC into alpha-ketobutyrate and ammonia. The decreased level of ethylene allows the plant to be more resistant to a wide environmental stress including plant pathogens... |
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Isolation of Rhizobacteria from Jatropha curcas and characterization of produced ACC deaminase.
J. Basic Microbiol. 52(3) , 285-95, (2012) Decreased levels of ACC (1-aminocyclopropane-1-carboxylic acid) result in lower levels of endogenous ethylene, which eliminate the potentially inhibitory effects of stress-induced higher ethylene concentrations. It is worth noting the substantial ability of t... |
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Asymmetric formal [3+2] cycloaddition reaction of isocyanoesters to 2-oxobutenoate esters by a multifunctional chiral silver catalyst.
Chemistry 17(28) , 7786-90, (2011)
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Acetohydroxyacid synthase, a novel target for improvement of L-lysine production by Corynebacterium glutamicum.
Appl. Environ. Microbiol. 75(2) , 419-27, (2009) The influence of acetohydroxy acid synthase (AHAS) on L-lysine production by Corynebacterium glutamicum was investigated. An AHAS with a deleted C-terminal domain in the regulatory subunit IlvN was engineered by truncating the ilvN gene. Compared to the wild-... |
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Elucidation of an alternate isoleucine biosynthesis pathway in Geobacter sulfurreducens.
J. Bacteriol. 190(7) , 2266-74, (2008) The central metabolic model for Geobacter sulfurreducens included a single pathway for the biosynthesis of isoleucine that was analogous to that of Escherichia coli, in which the isoleucine precursor 2-oxobutanoate is generated from threonine. 13C labeling st... |