Isovanillin
Isovanillin structure
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Common Name | Isovanillin | ||
|---|---|---|---|---|
| CAS Number | 621-59-0 | Molecular Weight | 152.147 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 308.1±0.0 °C at 760 mmHg | |
| Molecular Formula | C8H8O3 | Melting Point | 113-116 °C | |
| MSDS | Chinese USA | Flash Point | 119.9±15.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Synthesis and accumulation of aromatic aldehydes in an engineered strain of Escherichia coli.
J. Am. Chem. Soc. 136(33) , 11644-54, (2014) Aromatic aldehydes are useful in numerous applications, especially as flavors, fragrances, and pharmaceutical precursors. However, microbial synthesis of aldehydes is hindered by rapid, endogenous, and redundant conversion of aldehydes to their corresponding ... |
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3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors.
Bioorg. Med. Chem. 15 , 2006-15, (2007) Phenoloxidase (PO), also known as tyrosinase, is a key enzyme in insect development, responsible for catalyzing the hydroxylation of tyrosine into o-diphenols and the oxidation of o-diphenols into o-quinones. Inhibition of PO may provide a basis for novel env... |
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Systemic exposure to and disposition of catechols derived from Salvia miltiorrhiza roots (Danshen) after intravenous dosing DanHong injection in human subjects, rats, and dogs.
Drug Metab. Dispos. 43(5) , 679-90, (2015) DanHong injection is a Danshen (Salvia miltiorrhiza roots)-based injectable solution for treatment of coronary artery disease and ischemic stroke. Danshen catechols are believed to be responsible for the injection's therapeutic effects. This study aimed to ch... |
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Pd(II)-mediated cyclization of o-allylbenzaldehydes in water: a novel synthesis of isocoumarins.
Org. Lett. 14(18) , 4930-3, (2012) A novel, concise and efficient synthesis of substituted isocoumarins is disclosed. o-Allylbenzaldehydes prepared from isovanillin were mediated by PdCl(2)-CuCl(2) in water to undergo a domino reaction sequence, including 6-exo-trig cyclization, the addition o... |
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Aldehyde oxidase: an enzyme of emerging importance in drug discovery.
J. Med. Chem. 53 , 8441-60, (2010)
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Inhibition of Cancer Cell Proliferation and Antiradical Effects of Decoction, Hydroalcoholic Extract, and Principal Constituents of Hemidesmus indicus R. Br.
Phytother Res. 29 , 857-63, (2015) Indian Sarsaparilla (Hemidesmus indicus R. Br.) is widely used in Indian traditional medicine. In the present work, we explored the effects of decoction, traditional Ayurvedic preparation, and hydroalcoholic extract, a phytocomplex more traditionally studied ... |
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Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons.
J. Nat. Med. 65(3-4) , 417-23, (2011) Not only neuronal death but also neuritic atrophy and synaptic loss underlie the pathogenesis of Alzheimer's disease as direct causes of the memory deficit. Extracts of Siberian ginseng (the rhizome of Eleutherococcus senticosus) were shown to have protective... |
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Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.
Bioorg. Med. Chem. 16(19) , 8999-9008, (2008) A new family of naphthalenic analogues of phenstatins with modifications on the ketone-bridge has been synthesised. The synthesised compounds have been assayed for tubulin polymerisation inhibitory activity as well as for cytotoxic activity against cancer cel... |
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Synthesis of santiagonamine.
Org. Lett. 9(17) , 3255-7, (2007) The first total synthesis of santiagonamine (1) is achieved in 12 steps from isovanillin. A palladium-catalyzed Ullmann cross-coupling reaction and a photocyclization are the key steps in the synthesis. |
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Vanilloid derivatives as tyrosinase inhibitors driven by virtual screening-based QSAR models.
Drug Test. Anal. 3(3) , 176-81, (2011) A number of vanilloids have been tested as tyrosinase inhibitors using Ligand-Based Virtual Screening (LBVS) driven by QSAR (Quantitative Structure-Activity Relationship) models as the multi-agent classification system. A total of 81 models were used to scree... |