4-Hydroxypyridine
4-Hydroxypyridine structure
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Common Name | 4-Hydroxypyridine | ||
|---|---|---|---|---|
| CAS Number | 626-64-2 | Molecular Weight | 95.10 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 380.6±0.0 °C at 760 mmHg | |
| Molecular Formula | C5H5NO | Melting Point | 150-151 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 182.3±20.4 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Aminoacrylate intermediates in the reaction of Citrobacter freundii tyrosine phenol-lyase.
Biochemistry 45(31) , 9575-83, (2006) Tyrosine phenol-lyase (TPL) from Citrobacter freundii is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the reversible hydrolytic cleavage of l-Tyr to give phenol and ammonium pyruvate. The proposed reaction mechanism for TPL involves formatio... |
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Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.
ACS Chem. Biol. 7(9) , 1488-95, (2012) We present an integrated approach to identify and optimize a novel class of γ-secretase modulators (GSMs) with a unique pharmacological profile. Our strategy included (i) virtual screening through application of a recently developed protocol (PhAST), (ii) syn... |
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Characterization of subdomain IIA binding site of human serum albumin in its native, unfolded, and refolded states using small molecular probes.
J. Am. Chem. Soc. 130(32) , 10793-801, (2008) Subdomain IIA binding site of human serum albumin (HSA) was characterized by examining the change in HSA fluorescence in the native, unfolded, and refolded states. The study was carried out in the absence and presence of small molecular probes using steady-st... |
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Comparative induction of CYP1A1 expression by pyridine and its metabolites.
Arch. Biochem. Biophys. 378(2) , 299-310, (2000) We compared pyridine and five of its metabolites in terms of (i) in vivo induction of CYP1A1 expression in the lung, kidney, and liver in the rat and (ii) in vitro binding to, and activation of, the aryl hydrocarbon receptor (AhR) in cytosol from rat liver or... |
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Three-component synthesis of perfluoroalkyl- or perfluoroaryl-substituted 4-hydroxypyridine derivatives and their palladium-catalyzed coupling reactions.
J. Org. Chem. 75(3) , 726-32, (2010) A three-component reaction with lithiated alkoxyallenes, nitriles, and perfluorinated carboxylic acids as precursors led to a series of perfluoroalkyl- or perfluoroaryl-substituted 4-hydroxypyridine derivatives. These compounds were converted into 4-pyridyl n... |
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A new and flexible synthesis of 4-hydroxypyridines: rapid access to caerulomycins A, E and functionalized terpyridines.
Chemistry 15(28) , 6811-4, (2009)
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Comparison of the effects of pyridine and its metabolites on rat liver and kidney.
Toxicol. Lett. 85(3) , 173-8, (1996) In order to evaluate the possibility that the metabolism of pyridine may be important for its toxic actions, pyridine was compared with pyridine N-oxide, 2-hydroxypyridine, 3-hydroxypyridine, 4-hydroxypyridine and pyridinium methyliodide in rats given equal m... |
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Synthesis, activity and binding with DNA of [{trans-PtCl(NH(3))(2)}(2)micro-{trans-Pd(4-hydroxypyridine) (2) (H(2)N(CH(2))(6)NH(2))(2)]Cl(4) (TH8).
Med. Chem. 5(4) , 372-81, (2009) This paper describes the synthesis, characterization, cytotoxicity of a new trinuclear Pt-Pd-Pt complex code named TH8 containing two 4-hydroxypyridine ligands bound to the central metal ion. In addition to its activity against human ovarian cancer cell lines... |
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Binding of phenol and analogues to alanine complexes of tyrosine phenol-lyase from Citrobacter freundii: implications for the mechanisms of alpha,beta-elimination and alanine racemization.
Biochemistry 32(43) , 11591-9, (1993) We have examined the interaction of Citrobacter freundii tyrosine phenol-lyase with both L- and D-alanine. This enzyme catalyzes the racemization of alanine as a side reaction, in addition to the physiological beta-elimination of L-tyrosine to give phenol and... |
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Piericidins C5 and C6: new 4-pyridinol compounds produced by Streptomyces sp. and Nocardioides sp.
Bioorg. Med. Chem. 11(21) , 4569-75, (2003) Piericidins C5 (1) and C6 (2), two new members of the piericidin family, were isolated from a Streptomyces sp. and a Nocardioides sp., together with known piericidins C1 (3), C2 (4), C3 (5), C4 (6), D1 (7), and A3 (8). The structures were determined on the ba... |