Aminopicoline
Aminopicoline structure
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Common Name | Aminopicoline | ||
|---|---|---|---|---|
| CAS Number | 695-34-1 | Molecular Weight | 108.141 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 227.4±20.0 °C at 760 mmHg | |
| Molecular Formula | C6H8N2 | Melting Point | 96-99 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 114.0±9.0 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Guide to Receptors and Channels (GRAC), 4th Edition.
Br. J. Pharmacol. 158 Suppl 1 , S1-254, (2009)
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Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.
Eur. J. Med. Chem. 44 , 2877-87, (2009) A series of new 3-aroylpyrido[1,2-a]pyrimidines were synthesized from aryl methyl ketones in a simple two-step procedure and evaluated as nitric oxide synthases (NOS) inhibitors. In order to perform a structure-activity relationship study, different aroyl gro... |
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Actions of 4-methyl-2-aminopyridine on neuromuscular transmission and contractility of skeletal muscle.
Eur. J. Pharmacol. 70(1) , 53-7, (1981) 4-Methyl-2-aminopyridine (4M2AP) increased responses of isolated rat diaphragm and chick biventer cervicis nerve-muscle preparations to nerve stimulation but depressed responses to direct stimulation. Responses to acetylcholine were also increased while respo... |
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On the mechanism of action of 2-amino-4-methylpyridine, a morphine-like analgesic.
Arch. Int. Pharmacodyn. Ther. 247(2) , 275-82, (1980) 2-Amino-4-methylpyridine (2-AMP), when implanted into the ventral lateral thalamus of rats, does not cause stereotyped behavior. On the other hand, when compulsive biting and gnawing was evoked by thalamic implants of morphine (via stimulation of type 1 opiat... |
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Differential activity of NO synthase inhibitors as chemopreventive agents in a primary rat tracheal epithelial cell transformation system.
Neoplasia 4(4) , 332-6, (2002) A model to study the effectiveness of potential chemopreventive agents that inhibit neoplastic process by different mechanisms has been used to test the efficacy of seven nitric oxide synthase (NOS) inhibitors. Five selective inducible NOS (iNOS) inhibitors: ... |
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Rhodium(I)-catalyzed one-pot synthesis of dialkyl ketones from methanol and alkenes through directed sp3 C-H bond activation of N-methylamine.
Chem. Commun. (Camb.) (44) , 5779-81, (2008) The hydroacylation of methanol with alkenes was developed using a catalytic system consisting of Rh(I), 2-amino-4-picoline and benzoic acid; the reaction is speculated to occur by the initial N-methylation of 2-amino-4-picoline with methanol, and the subseque... |
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DNA binding ability and hydrogen peroxide induced nuclease activity of a novel Cu(II) complex with malonate as the primary ligand and protonated 2-amino-4-picoline as the counterion.
J. Phys. Chem. B 114(17) , 5851-61, (2010) The DNA binding property of a Cu(II) complex, viz., [Cu(mal)(2)](picH)(2).2H(2)O, (mal)(2) = malonic acid, picH = protonated 2-amino-4-picoline, has been investigated in this study. The binding of this complex with plasmid and chromosomal DNA has been charact... |
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Inhibition of nitric oxide synthase aggravates cisplatin-induced nephrotoxicity: effect of 2-amino-4-methylpyridine.
Chemotherapy 48(6) , 309-15, (2002) Nitric oxide (NO) has been shown to play a role in maintaining normal renal function. However, the role of NO in cisplatin (CDDP)-induced nephrotoxicity is still unclear. The aim of the present work was to examine the effect of the NO synthase (NOS) inhibitor... |
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Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity.
Bioorg. Med. Chem. Lett. 16(18) , 4946-50, (2006) An enkephalin analogue coupled to 'aminofentanyl' has been synthesized and tested for biological activities at the mu and delta opioid receptors. Aminofentanyl which represents a structural derivative of fentanyl has been synthesized by acylation of 1-(2-phen... |
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Analgesic activity of 2-amino-4-methylpyridine, a novel NO synthase inhibitor.
Inflamm. Res. 46 Suppl 2 , S135-6, (1997)
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