![]() 4-Nitrophenyl chloroformate structure
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Common Name | 4-Nitrophenyl chloroformate | ||
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CAS Number | 7693-46-1 | Molecular Weight | 201.564 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | 283.6±13.0 °C at 760 mmHg | |
Molecular Formula | C7H4ClNO4 | Melting Point | 77-79 °C(lit.) | |
MSDS | Chinese USA | Flash Point | 125.3±19.8 °C | |
Symbol |
![]() ![]() GHS05, GHS07 |
Signal Word | Danger |
In vivo performance and biocompatibility of a subcutaneous implant for real-time glucose-responsive insulin delivery.
Diabetes Technol. Ther. 17(4) , 255-67, (2015) An implantable, glucose-responsive insulin delivery microdevice was reported previously by our group, providing rapid insulin release in response to hyperglycemic events and efficacy in vivo over a 1-week period when implanted intraperitoneally in rats with d... |
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Cysteine-Functionalized Nanostructured Lipid Carriers for Oral Delivery of Docetaxel: A Permeability and Pharmacokinetic Study.
Mol. Pharm. 12 , 2384-95, (2015) Here we report the development and evaluation of cysteine-modified nanostructured lipid carriers (NLCs) for oral delivery of docetaxel (DTX). The NLCs ensure high encapsulation efficiency of docetaxel, while the cysteine bound the NLCs with PEG2000-monosteara... |
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Microstructured dextran hydrogels for burst-free sustained release of PEGylated protein drugs.
Biomaterials 63 , 146-57, (2015) Hydrogels have gained significant attention as ideal delivery vehicles for protein drugs. However, the use of hydrogels for protein delivery has been restricted because their porous structures inevitably cause a premature leakage of encapsulated proteins. Her... |
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In vivo bioluminescence imaging for viable human neural stem cells incorporated within in situ gelatin hydrogels.
EJNMMI Res. 4 , 61, (2015) Three-dimensional (3D) hydrogel-based stem cell therapies contribute to enhanced therapeutic efficacy in treating diseases, and determining the optimal mechanical strength of the hydrogel in vivo is important for therapeutic success. We evaluated the prolifer... |
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Synthesis and anticancer evaluation of benzyloxyurea derivatives.
Chem. Pharm. Bull. 62(9) , 898-905, (2014) A series of novel benzyloxyurea derivatives was designed, synthesized by substituting different benzyls or phenyls on N,N'-positions of the hydroxyurea (HU). These target compounds were evaluated for their anticancer activity in vitro against human leukemia c... |
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Tumor-Targeting Co-Delivery of Drug and Gene from Temperature-Triggered Micelles.
Macromol. Biosci. 15 , 1198-204, (2015) Co-delivery strategy using multifunctional nanocarriers is an attractive option for the synergistic and enhanced effects in cancer treatment, but one system integrating multiple functions for controlled release at the target is still challenging. Herein, this... |
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Lactoferrin-modified poly(ethylene glycol)-grafted BSA nanoparticles as a dual-targeting carrier for treating brain gliomas.
Mol. Pharm. 11(6) , 1823-34, (2014) In this study, a dual-targeting drug delivery system based on bovine serum albumin nanoparticles (BSA-NPs) modified with both lactoferrin (Lf) and mPEG2000 loading doxorubicin (DOX) was designed, and its blood-brain barrier (BBB) penetration and brain glioma ... |
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Stimulation of gene transfection by silicon nanowire arrays modified with polyethylenimine.
ACS Appl. Mater. Interfaces 6(16) , 14391-8, (2014) In this work, a novel gene delivery strategy was proposed based on silicon nanowire arrays modified with high-molecular-weight 25 kDa branched polyethylenimine (SN-PEI). Both the plasmid DNA (pDNA) binding capacity and the in vitro gene transfection efficienc... |
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A cleavable amino-thiol linker for reversible linking of amines to DNA.
J. Org. Chem. 71 , 9556, (2006) A cleavable heterobifunctional cross-linker for the reversible conjugation of amines to thiol-modified DNA has been developed and tested. The succinimidyl 2-(vinylsulfonyl)ethyl carbonate (SVEC) was prepared in three steps and tested for its ability to react ... |
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Preparation and in vitro characterization of pluronic-attached polyamidoamine dendrimers for drug delivery.
Drug Dev. Ind. Pharm. 41 , 812-8, (2015) Polyamidoamine (PAMAM) dendrimers have attracted lots of interest as drug carriers. And little study about whether pluronic-attached PAMAM dendrimers could be potential drug delivery systems has been carried on.Pluronic F127 (PF127) attached PAMAM dendrimers ... |