Carboplatin
Carboplatin structure
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Common Name | Carboplatin | ||
|---|---|---|---|---|
| CAS Number | 41575-94-4 | Molecular Weight | 371.254 | |
| Density | N/A | Boiling Point | 366.4ºCat 760 mmHg | |
| Molecular Formula | C6H12N2O4Pt | Melting Point | 228-230ºC | |
| MSDS | Chinese USA | Flash Point | 189.6ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer.
Oncotarget 5(21) , 10434-45, (2014) The successes of targeted therapeutics against EGFR and ALK in non-small cell lung cancer (NSCLC) have demonstrated the substantial survival gains made possible by precision therapy. However, the majority of patients do not have tumors with genetic alteration... |
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Graphene oxide - gelatin nanohybrids as functional tools for enhanced Carboplatin activity in neuroblastoma cells.
Pharm. Res. 32 , 2132-43, (2015) Preparation of Nanographene oxide (NGO) - Gelatin hybrids for efficient treatment of Neuroblastoma.Nanohybrids were prepared via non-covalent interactions. Spectroscopic tools have been used to discriminate the chemical states of NGO prior and after gelatin c... |
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CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome.
Oncotarget 5(15) , 6191-205, (2014) Malignant mesothelioma is a deadly tumor whose diagnosis and treatment remain very challenging. There is an urgent need to advance our understanding of mesothelioma biology and to identify new molecular markers for improving management of patients. CD157 is a... |
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Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells.
Gynecol. Oncol. 136(3) , 554-61, (2015) Significant reductions in gynecologic (GYN) cancer mortality and morbidity require treatments that prevent and reverse resistance to chemotherapy and radiation. The objective of this study was to determine if pharmacologic inhibition of key DNA damage respons... |
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Fast, Stable Induction of P-Glycoprotein-mediated Drug Resistance in BT-474 Breast Cancer Cells by Stable Transfection of ABCB1 Gene.
Anticancer Res. 35 , 2531-8, (2015) Patients with P-glycoprotein and HER2/neu (HER2) receptor-overexpressing breast cancer usually have poor clinical outcomes. However, there exist no commercially available breast cancer cell lines that are HER2/P-glycoprotein double-positive, which limits rese... |
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Biological, biochemical and biomechanical characterisation of articular cartilage from the porcine, bovine and ovine hip and knee.
Int. J. Clin. Exp. Pathol. 8(1) , 25-37, (2015) This study aimed to determine the optimal starting material for the development of an acellular osteochondral graft. Osteochondral tissues from three different species were characterised; pig (6 months), cow (18 months) and two ages of sheep (8-12 months and ... |
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Synthesis, in-vitro cytotoxic activity and DNA interactions of new dicarboxylatoplatinum(II) complexes with 2-hydroxymethylbenzimidazole as carrier ligands.
J. Pharm. Pharmacol. 66(11) , 1593-605, (2014) The aim of this study was to investigate the in-vitro cytotoxic activity of new platinum(II) complexes on the human HeLa (ER-), MCF-7 (ER+) and MDA-MB 231 (ER-) cell lines. Furthermore, we investigated plasmid DNA interactions and inhibition of BamHI and Hind... |
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Encapsulation in nanoparticles improves anti-cancer efficacy of carboplatin.
AAPS PharmSciTech 15(4) , 1029-38, (2014) Poor cellular uptake contributes to high dose requirement and limited therapeutic efficacy of the platinum-based anticancer drug carboplatin. Delivery systems that can improve the cellular accumulation of carboplatin will, therefore, likely improve its therap... |
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A shotgun approach for the identification of platinum-protein complexes.
Anal. Bioanal. Chem 407(9) , 2393-403, (2015) A shotgun approach including peptide-based OFFGEL-isoelectric focusing (IEF) fractionation has been developed with the aim of improving the identification of platinum-binding proteins in biological samples. The method is based on a filter-aided sample prepara... |
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Enhanced Antiproliferative Effect of Carboplatin in Cervical Cancer Cells Utilizing Folate-Grafted Polymeric Nanoparticles.
Nanoscale Res. Lett. 10 , 453, (2015) Carboplatin (CRB) possesses superior anticancer effect in cervical cancer cells with lower incidence of side effects compared to that of cisplatin. However, CRB suffers from severe side effects due to undesirable tissue distributions which contribute to the l... |