Azoxymethane
Azoxymethane structure
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Common Name | Azoxymethane | ||
|---|---|---|---|---|
| CAS Number | 25843-45-2 | Molecular Weight | 74.08180 | |
| Density | 0.98g/cm3 | Boiling Point | 92ºC at 760mmHg | |
| Molecular Formula | C2H6N2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 9.4ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon.
Mol. Cancer Res. 13 , 1478-86, (2015) The colon tumor microenvironment is becoming increasingly recognized as a complex but central player in the development of many cancers. Previously, we identified an oncogenic role for the mRNA-binding protein IMP1 (IGF2BP1) in the epithelium during colon tum... |
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The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis.
Oncotarget 6 , 19671-84, (2015) MUTYH DNA glycosylase removes mismatched adenine opposite 7, 8-dihydro-8-oxoguanine (8-oxoG), which is the major mutagenic lesion induced by oxidative stress. Biallelic mutations in MUTYH are associated with MUTYH-Associated polyposis (MAP) and increased risk... |
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15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway.
FASEB J. 29 , 2359-70, (2015) The IL-6/signal transducer and activator of transcription 3 (STAT3) pathway is a critical signaling pathway for colitis-associated colorectal cancer (CAC). Peroxisome proliferator-activated receptor (PPAR)-δ, a lipid nuclear receptor, up-regulates IL-6. 15-Li... |
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Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.
Cancer Res. 73(17) , 5473-84, (2013) Analysis of the Polyp Prevention Trial showed an association between an isorhamnetin-rich diet and a reduced risk of advanced adenoma recurrence; however, the mechanism behind the chemoprotective effects of isorhamnetin remains unclear. Here, we show that iso... |
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Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.
Carcinogenesis 35(12) , 2787-97, (2014) Cannabigerol (CBG) is a safe non-psychotropic Cannabis-derived cannabinoid (CB), which interacts with specific targets involved in carcinogenesis. Specifically, CBG potently blocks transient receptor potential (TRP) M8 (TRPM8), activates TRPA1, TRPV1 and TRPV... |
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Apple polysaccharide reduces NF-Kb mediated colitis-associated colon carcinogenesis.
Nutr. Cancer 67(1) , 177-90, (2015) Nuclear factor-kappa B (NF-κB) is an important molecule in mediating inflammatory colitis, which can lead to colorectal cancer (CRC). The aim of this study was to evaluate the chemopreventive efficacy of apple polysaccharide extract (AP) in inhibiting NF-κB-m... |
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Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity.
Mol. Nutr. Food. Res. 58(12) , 2274-85, (2014) This study determined the efficacy of carnosic acid (CA) for suppressing colon carcinogenesis associated with excess adiposity.Cell growth regulation by CA was evaluated in HT-29 colon adenocarcinoma cells cocultured with 3T3-L1 adipocytes. To determine the i... |
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Autophagy Protects against Colitis by the Maintenance of Normal Gut Microflora and Secretion of Mucus.
J. Biol. Chem. 290 , 20511-26, (2015) Genome-wide association studies of inflammatory bowel diseases identified susceptible loci containing an autophagy-related gene. However, the role of autophagy in the colon, a major affected area in inflammatory bowel diseases, is not clear. Here, we show tha... |
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CD80-CD28 signaling controls the progression of inflammatory colorectal carcinogenesis.
Oncotarget 6 , 20058-69, (2015) In patients with ulcerative colitis (UC) the cumulative risk of colon cancer is lower than the actual rate of dysplasia suggesting an efficient immune surveillance mechanism. Since the co-stimulatory molecule CD80 is overexpressed in dysplastic colonic mucosa... |
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A SMYD3 Small-Molecule Inhibitor Impairing Cancer Cell Growth.
J. Cell Physiol. 230 , 2447-60, (2015) SMYD3 is a histone lysine methyltransferase that plays an important role in transcriptional activation as a member of an RNA polymerase complex, and its oncogenic role has been described in different cancer types. We studied the expression and activity of SMY... |