Verapamil HCl
Verapamil HCl structure
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Common Name | Verapamil HCl | ||
|---|---|---|---|---|
| CAS Number | 152-11-4 | Molecular Weight | 491.063 | |
| Density | 1.058g/cm3 | Boiling Point | 586.1ºC at 760 mmHg | |
| Molecular Formula | C27H39ClN2O4 | Melting Point | 142 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 308.3ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.
Drug Metab. Pharmacokinet. 29(5) , 419-26, (2014) In central nervous system drug discovery, cerebrospinal fluid (CSF) drug concentration (C(CSF)) has been widely used as a surrogate for unbound brain concentrations (C(u,brain)). However, previous rodent studies demonstrated that when drugs undergo active eff... |
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Salt effects in electromembrane extraction.
J. Chromatogr. A. 1347 , 1-7, (2014) Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs ... |
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In vivo epithelial wound repair requires mobilization of endogenous intracellular and extracellular calcium.
J. Biol. Chem. 288(47) , 33585-97, (2013) We report that a localized intracellular and extracellular Ca(2+) mobilization occurs at the site of microscopic epithelial damage in vivo and is required to mediate tissue repair. Intravital confocal/two-photon microscopy continuously imaged the surgically e... |
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A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport.
Aquat. Toxicol. 159 , 127-37, (2015) The gill is the principle site of xenobiotic transfer to and from the aqueous environment. To replace, refine or reduce (3Rs) the large numbers of fish used in in vivo uptake studies an effective in vitro screen is required that mimics the function of the tel... |
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Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges".
Int. J. Cancer 136(4) , E188-96, (2015) ATP-binding cassette (ABC) drug transporters consuming ATPs for drug efflux is a common mechanism by which clinical cancers develop multidrug resistance (MDR). We hypothesized that MDR phenotypes could be suppressed by administration of "ersatzdroges," nonche... |
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Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.
Circulation 127(16) , 1677-91, (2013) Cardiotoxicity is a leading cause for drug attrition during pharmaceutical development and has resulted in numerous preventable patient deaths. Incidents of adverse cardiac drug reactions are more common in patients with preexisting heart disease than the gen... |
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Bronchodilator, vasodilator and spasmolytic activities of Cymbopogon martinii.
J. Physiol. Pharmacol. 65(6) , 859-66, (2015) Cymbopogon martinii (Cm.Cr) is traditionally used in south Asian communities for the management of multiple ailments including gastrointestinal, respiratory and vascular disorders and the present study was undertaken to validate these folkloric uses. The appl... |
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Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.
Antimicrob. Agents Chemother. 58(6) , 3168-76, (2014) Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS c... |
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Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease.
Autophagy 11(2) , 385-402, (2015) Mitochondria-induced oxidative stress and flawed autophagy are common features of neurodegenerative and lysosomal storage diseases (LSDs). Although defective autophagy is particularly prominent in Pompe disease, mitochondrial function has escaped examination ... |
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Vaginal expression of efflux transporters and the potential impact on the disposition of microbicides in vitro and in rabbits.
Mol. Pharm. 11(12) , 4405-14, (2014) In order to reach sufficiently high tissue concentrations and thus be effective, vaginally applied anti-HIV microbicides that are active at the level of the immune cells must permeate across the cervicovaginal mucosal layer. Cellular efflux transporters, such... |