Cortistatin 14

Cortistatin 14 Structure
Cortistatin 14 structure
Common Name Cortistatin 14
CAS Number 186901-48-4 Molecular Weight 1721.01000
Density N/A Boiling Point N/A
Molecular Formula C81H114N20O18S2 Melting Point N/A
MSDS Chinese USA Flash Point N/A

The cortical neuropeptide, cortistatin-14, impairs post-training memory processing.

Brain Res. 775 , 250-252, (1997)

Cortistatin-14, a neuropeptide, is present primarily in the cortex and hippocampus. In the hippocampus, cortistatin-14 inhibits pyramidal cell firing and co-exists with GABA. To determine if cortistatin-14 would impair retention, saline or cortistatin-14 were...

Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions.

Brain Res. Brain Res. Rev. 33 , 228-241, (2000)

Cortistatin is a recently discovered neuropeptide relative of somatostatin named after its predominantly cortical expression and ability to depress cortical activity. Cortistatin-14 shares 11 of the 14 amino acids of somatostatin-14 yet their nucleotide seque...

Structural and compositional determinants of cortistatin activity.

J. Neurosci. 56 , 611-619, (1999)

Cortistatin-14 (CST-14) is a putative novel neuropeptide that shares 11 of its 14 residues with somatostatin-14 (SRIF-14), yet its effects on sleep physiology, locomotor behavior and hippocampal function are different from those of somatostatin. We studied th...

Roles for NHERF1 and NHERF2 on the regulation of C3a receptor signaling in human mast cells.

PLoS ONE 7 , e51355, (2013)

The anaphylatoxin C3a binds to the G protein coupled receptor (GPCR, C3aR) and activates divergent signaling pathways to induce degranulation and cytokine production in human mast cells. Adapter proteins such as the Na(+)/H(+) exchange regulatory factor (NHER...