Cortistatin 14

Modify Date: 2025-08-26 22:30:08

Cortistatin 14 structure	Common Name	Cortistatin 14
	CAS Number	186901-48-4	Molecular Weight	1721.01000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈₁H₁₁₄N₂₀O₁₈S₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Cortistatin 14

Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties[1][2][3][4].

Name	Cortistatin-14
Synonym	More Synonyms

Description	Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties[1][2][3][4].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
References	[1]. De Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5. [2]. Baranowska B, et al. Cortistatin and pituitary hormone secretion in rat. J Physiol Pharmacol. 2009 Mar;60(1):151-6. [3]. Braun H, et al. Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain. Brain Res. 1998 Aug 24;803(1-2):54-60. [4]. Markovics A, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

References

[1]. De Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5.

[2]. Baranowska B, et al. Cortistatin and pituitary hormone secretion in rat. J Physiol Pharmacol. 2009 Mar;60(1):151-6.

[3]. Braun H, et al. Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain. Brain Res. 1998 Aug 24;803(1-2):54-60.

[4]. Markovics A, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50.

Molecular Formula	C₈₁H₁₁₄N₂₀O₁₈S₂
Molecular Weight	1721.01000
Exact Mass	1719.79000
PSA	675.86000
LogP	3.12890
InChIKey	DDRPLNQJNRBRNY-WYYADCIBSA-N
SMILES	CC(O)C1NC(=O)C(CCCCN)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccccc2)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C2CCCN2)CSSCC(C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(Cc2ccccc2)NC1=O
Storage condition	−20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

The cortical neuropeptide, cortistatin-14, impairs post-training memory processing.

Brain Res. 775 , 250-252, (1997)

Cortistatin-14, a neuropeptide, is present primarily in the cortex and hippocampus. In the hippocampus, cortistatin-14 inhibits pyramidal cell firing and co-exists with GABA. To determine if cortistat...

Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions.

Brain Res. Brain Res. Rev. 33 , 228-241, (2000)

Cortistatin is a recently discovered neuropeptide relative of somatostatin named after its predominantly cortical expression and ability to depress cortical activity. Cortistatin-14 shares 11 of the 1...

Structural and compositional determinants of cortistatin activity.

J. Neurosci. 56 , 611-619, (1999)

Cortistatin-14 (CST-14) is a putative novel neuropeptide that shares 11 of its 14 residues with somatostatin-14 (SRIF-14), yet its effects on sleep physiology, locomotor behavior and hippocampal funct...

cortistatin14

Cortistatin 14

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Cortistatin 14

Use of Cortistatin 14

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Cortistatin 14 Biological Activity

Chemical & Physical Properties

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Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.