Carbachol
Carbachol structure
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Common Name | Carbachol | ||
|---|---|---|---|---|
| CAS Number | 51-83-2 | Molecular Weight | 182.648 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C6H15ClN2O2 | Melting Point | 200-204 ºC | |
| MSDS | Chinese USA | Flash Point | 90°C(lit.) | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.
Nat. Commun. 5 , 4431, (2014) Tumour suppressor PTEN is a phosphatase that negatively regulates the PI3K/AKT pathway. The ability to directly monitor PTEN conformation and function in a rapid, sensitive manner is a key step towards developing anti-cancer drugs aimed at enhancing or restor... |
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Taurolithocholic acid promotes intrahepatic cholangiocarcinoma cell growth via muscarinic acetylcholine receptor and EGFR/ERK1/2 signaling pathway.
Int. J. Oncol. 46 , 2317-26, (2015) Cholangiocarcinoma (CCA) is a malignant cancer of the biliary tract and its occurrence is associated with chronic cholestasis which causes an elevation of bile acids in the liver and bile duct. The present study aimed to investigate the role and mechanistic e... |
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Involvement of the Tyr kinase/JNK pathway in carbachol-induced bronchial smooth muscle contraction in the rat.
Anesthesiology 118(5) , 1076-85, (2013) Tyrosine (Tyr) kinases and mitogen-activated protein kinases have been thought to participate in the contractile response in various smooth muscles. The aim of the current study was to investigate the involvement of the Tyr kinase pathway in the contraction o... |
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Cholinergic signalling-regulated KV7.5 currents are expressed in colonic ICC-IM but not ICC-MP.
Pflugers Arch. 466(9) , 1805-18, (2014) Interstitial cells of Cajal (ICC) and the enteric nervous system orchestrate the various rhythmic motor patterns of the colon. Excitation of ICC may evoke stimulus-dependent pacemaker activity and will therefore have a profound effect on colonic motility. The... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide.
Pulm. Pharmacol. Ther. 28(2) , 114-21, (2014) This study characterised the in vitro and in vivo profiles of two novel long-acting muscarinic antagonists, aclidinium bromide and glycopyrronium bromide, using tiotropium bromide and ipratropium bromide as comparators. All four antagonists had high affinity ... |
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The GPR55 agonist lysophosphatidylinositol relaxes rat mesenteric resistance artery and induces Ca(2+) release in rat mesenteric artery endothelial cells.
Br. J. Pharmacol. 172 , 3043-57, (2015) Lysophosphatidylinositol (LPI), a lipid signalling molecule, activates GPR55 and elevates intracellular Ca(2+). Here, we examine the actions of LPI in the rat resistance mesenteric artery and Ca(2+) responses in endothelial cells isolated from the artery.Vasc... |
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Influenza A infection attenuates relaxation responses of mouse tracheal smooth muscle evoked by acrolein.
Biochem. Pharmacol. 93(4) , 519-26, (2015) The airway epithelium is an important source of relaxant mediators, and damage to the epithelium caused by respiratory tract viruses may contribute to airway hyperreactivity. The aim of this study was to determine whether influenza A-induced epithelial damage... |