3-methyluracil
3-methyluracil structure
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Common Name | 3-methyluracil | ||
|---|---|---|---|---|
| CAS Number | 608-34-4 | Molecular Weight | 126.11300 | |
| Density | 1.263 g/cm3 | Boiling Point | 260.1ºC at 760 mmHg | |
| Molecular Formula | C5H6N2O2 | Melting Point | 55-57ºC | |
| MSDS | USA | Flash Point | 111.1ºC | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Uracil and thymine reactivity in the gas phase: the S(N)2 reaction and implications for electron delocalization in leaving groups.
J. Am. Chem. Soc. 131 , 18376-18385, (2009) The gas-phase substitution reactions of methyl chloride and 1,3-dimethyluracil (at the N1-CH(3)) are examined computationally and experimentally. It is found that, although hydrochloric acid and 3-methyluracil are similar in acidity, the leaving group abiliti... |
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Pulse radiolytic studies of radicals produced from methylated uracils via oxidation by SO4..
Radiat. Res. 114(2) , 207-14, (1988) Using a pulse radiolysis technique, some nucleic base radicals were produced by the reactions of sulfate radical, SO4-, with 1-, 3-, 5-, and 6-methyluracils, and their optical and kinetic natures were observed. All of their absorption spectra showed main peak... |
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Ab initio investigation of the methylation and hydration effects on the electronic spectra of uracil and thymine.
Phys. Chem. Chem. Phys. 12 , 4915-4923, (2010) In this work we investigated the lowest-lying electronic excitations for a series of methyl-substituted uracil derivatives, i.e., uracil, 1-methyluracil, 3-methyluracil, thymine, 1-methylthymine, 1,3-dimethyluracil, 3-methylthymine, 1,3-dimethylthymine, and t... |
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Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.
FEBS Lett. 582 , 3313-3319, (2008) The human obesity susceptibility gene, FTO, encodes a protein that is homologous to the DNA repair AlkB protein. The AlkB family proteins utilize iron(II), alpha-ketoglutarate (alpha-KG) and dioxygen to perform oxidative repair of alkylated nucleobases in DNA... |
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Vibrational Feshbach resonances in uracil and thymine.
J. Chem. Phys. 124(12) , 124310, (2006) Sharp peaks in the dissociative electron attachment (DEA) cross sections of uracil and thymine at energies below 3 eV are assigned to vibrational Feshbach resonances (VFRs) arising from coupling between the dipole bound state and the temporary anion state ass... |
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Crystal structure of the FTO protein reveals basis for its substrate specificity.
Nature 464(7292) , 1205-9, (2010) Recent studies have unequivocally associated the fat mass and obesity-associated (FTO) gene with the risk of obesity. In vitro FTO protein is an AlkB-like DNA/RNA demethylase with a strong preference for 3-methylthymidine (3-meT) in single-stranded DNA or 3-m... |
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NAT2 and CYP1A2 phenotyping with caffeine: head-to-head comparison of AFMU vs. AAMU in the urine metabolite ratios.
Br. J. Clin. Pharmacol. 55(1) , 62-7, (2003) (i) To compare the phenotyping of healthy subjects for NAT2 and CYP1A2 activities with caffeine, by the simultaneous assay of the urinary metabolites AFMU and AAMU, and (ii) to ascertain whether NAT2 and CYP1A2 phenotyping is influenced by the use of AFMU or ... |
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Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3-L1 adipocytes.
Biofactors 34(4) , 293-302, (2008) To understand the mechanisms of the anti-obesity effects of dietary caffeine, the effects of caffeine and its metabolites on adipocyte differentiation and insulin-stimulated glucose uptake in murine 3T3-L1 adipocytes were investigated. Caffeine did not inhibi... |
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Vibrational Feshbach resonances in uracil and thymine. Burrow PD, Gallup GA, et al.
J. Chem. Phys. 28 , 124310, (2006)
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