1-Octylguanidine hemisulfate
1-Octylguanidine hemisulfate structure
|
Common Name | 1-Octylguanidine hemisulfate | ||
|---|---|---|---|---|
| CAS Number | 21409-35-8 | Molecular Weight | 220.32 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | CH3(CH2)7NHC(=NH)NH2·1/2H2SO4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Inactivation of mitochondrial permeability transition pore by octylguanidine and octylamine.
J. Bioenerg. Biomembr. 32(2) , 193-8, (2000) Mitochondrial permeability transition occurs through a Ca2+-dependent opening of a transmembrane pore, whose identity has been attributed to that of the adenine nucleotide translocase (ANT). In this work, we induced permeability transition by adding 0.5 micro... |
|
|
Environment-selective synergism using self-assembling cytotoxic and antimicrobial agents.
Biochem. Pharmacol. 37(23) , 4505-12, (1988) Environment-selective synergistic toxicity using combinations of aldehydes and hydrazine derivatives was demonstrated in two different model systems in vitro. Combinations of 5-nitro-2-furaldehyde with semi-carbazide and of 2-hydrazinopyridine with pyridine-2... |
|
|
Myocardial protective effect of octylguanidine against the damage induced by ischemia reperfusion in rat heart.
Mol. Cell Biochem. 269(1-2) , 19-26, (2005) This study shows that the hydrophobic cation octylguanidine protects against myocardial damage induced by ischemia-reperfusion. The protective effect of the amine was analyzed after 5 min of coronary occlusion followed by 5 min reperfusion in rat hearts. ECG ... |
|
|
Effects of octylguanidine on heart activity: 2. Mechanical cardiac response of guinea-pig as compared to Xenopus.
Boll. Soc. Ital. Biol. Sper. 56(6) , 625-9, (1980) The effects of octylguanidine on the mechanical activity of Guinea-pig heart were investigated. The negative inotropic effect took place in a biphasic manner with a first fast contraction decline process followed, after a temporaneous steady state, by a secon... |
|
|
Effects of octylguanidine on heart activity: 1. Electrical cardiac response of guinea-pig as compared to Xenopus.
Boll. Soc. Ital. Biol. Sper. 56(6) , 619-24, (1980) The effects of octylguanidine on electrical activity of Guinea-pig heart were investigated. The substance (2.7 x 10(-4)M) initially reduced the rate of rise of the action potential without a concomitant modification of the other action potential without a con... |
|
|
Interactions of pyrethroids and octylguanidine with sodium channels of squid giant axons.
Brain Res. 445(1) , 1-11, (1988) Kinetics of pyrethroid-modified sodium channels and the interaction of N-octylguanidine with the modified channels have been studied with internally perfused and voltage-clamped squid giant axons. The pyrethroids used were 1R-cis-phenothrin; 1R-cis-permethrin... |
|
|
In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition.
Biochim. Biophys. Acta 1767(10) , 1245-51, (2007) In yeast, Ca(2+) and long chain alkylguanidines interact with mitochondria modulating the opening of the yeast mitochondrial unspecific channel. Mammalians possess a similar structure, the mitochondrial permeability transition pore. The composition of these p... |
|
|
Effects of drugs on acetylcholine-activated ionic channels of internally perfused chick myoballs.
J. Physiol. 337 , 753-68, (1983) The effects of intracellular application of three compounds - QX314, N-ethylguanidine and N-octylguanidine - on the acetylcholine-activated ionic channels in chick myoballs were examined. Voltage-clamped myoballs were internally perfused using the suction-pip... |
|
|
Interactions of monovalent cations with sodium channels in squid axon. II. Modification of pharmacological inactivation gating.
J. Gen. Physiol. 85 , 603-620, (1985) The time-, frequency-, and voltage-dependent blocking actions of several cationic drug molecules on open Na channels were investigated in voltage-clamped, internally perfused squid giant axons. The relative potencies and time courses of block by the agents (p... |
|
|
Magnesium and octylguanidinium inhibition of monovalent cation translocation in mitochondria.
Acta Physiol. Pharmacol. Latinoam. 36(3) , 217-32, (1986) We have studied the inhibitory effects of several cations (OG+, Mg2+, Ca2+, Sr2+, Ba2+, Mn2+, La3+) on the uniport and exchange pathways for Na+ and K+ of rat liver mitochondria. Swelling of mitochondria suspended in sodium or potassium acetates indicates tha... |