Histone, from calf thymus
Histone, from calf thymus structure
|
Common Name | Histone, from calf thymus | ||
|---|---|---|---|---|
| CAS Number | 9064-47-5 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
|
Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.
J. Biol. Chem. 290 , 16723-43, (2015) Human protein arginine methyltransferase (PRMT) 9 symmetrically dimethylates arginine residues on splicing factor SF3B2 (SAP145) and has been functionally linked to the regulation of alternative splicing of pre-mRNA. Site-directed mutagenesis studies on this ... |
|
|
Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1.
Eur. J. Med. Chem. 105 , 80-105, (2015) Using a structure-based design approach, we have developed a new series of imidazo[1,2-b]pyridazines, targeting the calcium-dependent protein kinase-1 (CDPK1) from Toxoplasma gondii. Twenty derivatives were thus synthesized. Structure-activity relationships a... |
|
|
No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro.
PLoS Pathog. 107 , 2884-2889, (2010) CDK5/p35 is a cyclin-dependent kinase essential for normal neuron function. Proteolysis of the p35 subunit in vivo results in CDK5/p25 that causes neurotoxicity associated with a number of neurodegenerative diseases. Whereas the mechanism by which conversion ... |
|
|
RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation.
Nucleic Acids Res. 42(21) , 13026-38, (2014) The JmjC-containing lysine demethylase, KDM4D, demethylates di-and tri-methylation of histone H3 on lysine 9 (H3K9me3). How KDM4D is recruited to chromatin and recognizes its histone substrates remains unknown. Here, we show that KDM4D binds RNA independently... |
|
|
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.
Nature 466 , 508-12, (2010) While reversible histone modifications are linked to an ever-expanding range of biological functions, the demethylases for histone H4 lysine 20 and their potential regulatory roles remain unknown. Here we report that the PHD and Jumonji C (JmjC) domain-contai... |
|
|
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase.
Hum. Mol. Genet. 19 , 217-22, (2010) Mutations of human PHF8 cluster within its JmjC encoding exons and are linked to mental retardation (MR) and a cleft lip/palate phenotype. Sequence comparisons, employing structural insights, suggest that PHF8 contains the double stranded beta-helix fold and ... |
|
|
The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis.
Mol. Cancer Ther. 29 , 266-80, (2009) Human STAGA is a multisubunit transcriptional coactivator containing the histone acetyltransferase GCN5L. Previous studies of the related yeast SAGA complex have shown that the yeast Gcn5, Ada2, and Ada3 components form a heterotrimer that is important for th... |
|
|
Chitosan oligosaccharides modulate the supramolecular conformation and the biological activity of oligogalacturonides in Arabidopsis.
Glia 20 , 775-86, (2010) Plant cell walls undergo remodeling during growth and development and are the first target of many invading pathogens. Acidic pectin (homogalacturonans) binds calcium and forms chain dimers called egg boxes and even multimers at higher calcium ion concentrati... |
|
|
Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice.
Hepatology 54 , 999-1008, (2011) Sterile inflammatory insults are known to activate innate immunity and propagate organ damage through the recognition of extracellular damage-associated molecular pattern (DAMP) molecules. Although DAMPs such as endogenous DNA and nuclear high-mobility group ... |
|
|
Histone methylation by NUE, a novel nuclear effector of the intracellular pathogen Chlamydia trachomatis.
PLoS Pathog. 6 , e1000995, (2010) Sequence analysis of the genome of the strict intracellular pathogen Chlamydia trachomatis revealed the presence of a SET domain containing protein, proteins that primarily function as histone methyltransferases. In these studies, we demonstrated secretion of... |