VAS 2870
VAS 2870 structure
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Common Name | VAS 2870 | ||
|---|---|---|---|---|
| CAS Number | 722456-31-7 | Molecular Weight | 360.392 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 627.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C18H12N6OS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 333.0±34.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Sex differences in the role of NADPH oxidases in endothelium-dependent vasorelaxation in porcine isolated coronary arteries.
Vascul. Pharmacol. 72 , 83-92, (2015) The present study examined whether vascular function, expression and activity of NADPH oxidases differ between sexes in porcine isolated coronary arteries (PCAs) using selective Nox inhibitors, ML-171 and VAS2870. Vascular responses of distal PCAs were examin... |
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Nox1 upregulates the function of vascular T-type calcium channels following chronic nitric oxide deficit.
Pflugers Arch. 467(4) , 727-35, (2015) Cardiovascular disease is characterised by reduced nitric oxide bioavailability resulting from oxidative stress. Our previous studies have shown that nitric oxide deficit per se increases the contribution of T-type calcium channels to vascular tone through in... |
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Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity.
Sci. Rep. 6 , 23135, (2016) Prostate cancer (PCa) is the leading malignancy among men. Importantly, this disease is mostly diagnosed at early stages offering a unique chemoprevention opportunity. Therefore, there is an urgent need to identify and target signaling molecules with higher e... |
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Role of homocysteinylation of ACE in endothelial dysfunction of arteries.
Am. J. Physiol. Heart Circ. Physiol. 308(2) , H92-100, (2015) The direct impact of de novo synthesis of homocysteine (Hcy) and its reactive metabolites, Hcy-S-S-Hcy and Hcy thiolactone (HCTL), on vascular function has not been fully elucidated. We hypothesized that Hcy synthesized within endothelial cells affects activi... |
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Oxidative stress induces early-onset apoptosis of vascular smooth muscle cells and neointima formation in response to injury.
Biosci. Rep. 35 , (2015) The present study dissects the mechanisms underlying the rapid onset of apoptosis that precedes post injury vascular remodelling. Using the rat balloon injury model, we demonstrated that a significant number of arterial vascular smooth muscle cells (VSMC) und... |