SR 142948A
SR 142948A structure
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Common Name | SR 142948A | ||
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| CAS Number | 184162-21-8 | Molecular Weight | 722.313 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H51N5O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist.
J. Pharmacol. Exp. Ther. 280(2) , 802-12, (1997) SR 142948A, 2-[[5-(2,6-dimethoxyphenyl)-1-(4-(N-(3-dimethylaminopropyl)-N-methylc arbamoyl)-2-isopropylphenyl)-1H-pyrazole3-carbonyl]amino] adamantane-2-carboxylic acid, hydrochloride, a new and extremely potent neurotensin (NT) receptor antagonist, has been ... |
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Neurotensin receptor antagonist SR 142948A alters Fos expression and extrapyramidal side effect profile of typical and atypical antipsychotic drugs.
Biol. Psychiatry 29(12) , 2200-7, (2004) Antipsychotic drugs (APDs) have previously been shown to alter Fos expression in a regionally specific manner. Increases in Fos expression in the nucleus accumbens (NAcc) are common to all clinically effective APDs. In contrast, APD-induced Fos expression inc... |
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Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cells.
Mol. Oncol. 3(3) , 204-13, (2009) Pancreatic adenocarcinomas express neurotensin receptors in up to 90% of cases, however, their role in tumor biology and as a drug target is not clear. In the present study, a stable neurotensin (NT) analog induced intracellular calcium release and intracellu... |