n-Butyl lactate
n-Butyl lactate structure
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Common Name | n-Butyl lactate | ||
|---|---|---|---|---|
| CAS Number | 138-22-7 | Molecular Weight | 146.184 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 189.4±8.0 °C at 760 mmHg | |
| Molecular Formula | C7H14O3 | Melting Point | −28 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 69.4±0.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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An insight on human skin penetration of diflunisal: lipogel versus hydrogel microemulsion.
Drug Dev. Ind. Pharm. 41(1) , 141-7, (2014) Diflunisal is a NSAID used in acute and long term management of pain and inflammation associated with osteoarthritis, rheumatoid arthritis and symptoms of primary dysmenorrhea. However, its oral use is associated with side effects such as peptic ulceration, d... |
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Optimization, ex vivo permeation, and stability study of lipid nanocarrier loaded gelatin capsules for treatment of intermittent claudication.
Int. J. Nanomedicine 10 , 4459-78, (2015) In this study, an optimized nanodispersible oral dosage form (containing a lactate ester) was developed for cilostazol (CZL). CZL is a phosphodiesterase inhibitor used for intermittent claudication. We aimed to improve the dissolution rate and absorption of C... |
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Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique.
Int. J. Pharm. 257(1-2) , 153-60, (2003) A preparation method for nanoparticles based on the emulsification of a butyl lactate or benzyl alcohol solution of a solid lipid in an aqueous solution of different emulsifiers, followed by dilution of the emulsion with water, was used to prepare glyceryl mo... |
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Preparation of griseofulvin nanoparticles from water-dilutable microemulsions.
Int. J. Pharm. 254(2) , 235-42, (2003) Nanoparticles of griseofulvin, a model drug with poor solubility and low bioavailability, were prepared from water dilutable microemulsions by the solvent diffusion technique. Solvent-in-water microemulsion formulations containing water, butyl lactate, lecith... |
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Safety assessment of lactate esters.
Regul Toxicol Pharmacol 27(2) , 88-97, (1998) Lactate esters have an oral LD50 greater than 2000 mg/kg and the inhalation LC50 is generally above 5000 mg/m3 and they may be potential eye and skin irritants, but not skin sensitizers. No evidence of teratogenicity or maternal toxicity was observed in an in... |
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Lipase-catalyzed transformations for the synthesis of butyl lactate: a comparison between esterification and transesterification.
Biotechnol. Prog. 22(2) , 444-8, (2006) The alpha-hydroxy esters are increasingly employed in cosmetic, food, and pharmaceutical formulations as they determine reduced skin-irritant effects in comparison with the respective acids, offering similar hygroscopic, emulsifying, and exfoliating propertie... |
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Optical resolution of n-butyl D- and L-lactates using immobilized lipase catalyst.
J. Biosci. Bioeng. 111(1) , 19-21, (2011) n-Butyl D- and L-lactates (BuDLa and BuLLa) were incubated with immobilized lipase. (1)H-NMR showed that BuDLa reacted to oligomers, while BuLLa did not react. A mixture containing 90.4% of BuLLa and 9.6% of BuDLa was incubated with the enzyme for 72 h, then ... |
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Microemulsions with butyl lactate as cosurfactant. Comelles F and Pascual A.
J. Dispers. Sci. Technol. 18(2) , 161-75, (1997)
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