Broxuridine
Broxuridine structure
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Common Name | Broxuridine | ||
|---|---|---|---|---|
| CAS Number | 59-14-3 | Molecular Weight | 307.098 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C9H11BrN2O5 | Melting Point | 191-194 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current.
Oncotarget 5(22) , 11252-68, (2014) Epidemiological and preclinical studies propose that metformin, a first-line drug for type-2 diabetes, exerts direct antitumor activity. Although several clinical trials are ongoing, the molecular mechanisms of this effect are unknown. Here we show that chlor... |
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Transplantation of enteric neural stem/progenitor cells into the irradiated young mouse hippocampus.
Cell. Transplant. 23(12) , 1657-71, (2015) Radiotherapy is an effective treatment for brain tumors but often results in cognitive deficits in survivors. Transplantation of embryonic or brain-derived neural stem/progenitor cells (BNSPCs) ameliorated cognitive impairment after irradiation (IR) in animal... |
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FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis.
Cardiovasc. Res. 105(1) , 107-17, (2014) The recombinant epidermal growth factor-like domain plus the serine/threonine-rich domain of thrombomodulin (rTMD23) promotes angiogenesis and accelerates the generation of activated protein C (APC), which facilitates angiogenesis. The aim of this study was t... |
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Regulation of insulin-like growth factor signaling by metformin in endometrial cancer cells.
Oncol. Lett. 8(5) , 1993-1999, (2014) Obesity, diabetes and insulin resistance are marked risk factors that promote the development of type I endometrial cancer. Previous studies have demonstrated that insulin-like growth factor 1 (IGF-1) and IGF-2 promote cell proliferation in endometrial cancer... |
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Soluble endoglin antagonizes Met signaling in spindle carcinoma cells.
Carcinogenesis 36(2) , 212-22, (2015) Increased levels of soluble endoglin (Sol-Eng) correlate with poor outcome in human cancer. We have previously shown that shedding of membrane endoglin, and concomitant release of Sol-Eng is a late event in chemical mouse skin carcinogenesis associated with t... |
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Recombinant HE4 protein promotes proliferation of pancreatic and endometrial cancer cell lines.
Oncol. Rep. 35 , 163-70, (2015) Pancreatic adenocarcinoma is one of the most deadly malignancies, and endometrial cancer represents the most common gynecologic cancer in the USA. Better understanding on the pathologic mechanisms and pathways is required for effective treatment of these mali... |
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G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients.
Mol. Neurobiol. 52 , 386-98, (2015) Parkinson's disease (PD) is the second most prevalent neurodegenerative disease among aging individuals, affecting greatly the quality of their life. However, the pathogenesis of Parkinson's disease is still incompletely understood to date. Increasing experim... |
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The impact of CLAUDIN-1 on follicular thyroid carcinoma aggressiveness.
Endocr. Relat. Cancer 22 , 819-30, (2015) CLAUDIN-1 belongs to the family of transmembrane tight junction proteins tightening the paracellular cleft of epithelial cells. In human malignancies, CLAUDIN-1 is often dysregulated and located in subcellular compartments, particularly in the nucleus where i... |
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APC selectively mediates response to chemotherapeutic agents in breast cancer.
BMC Cancer 15 , 457, (2015) The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated or hypermethylated in up to 70% of sporadic breast cancers depending on subtype; however, the effects of APC mutation on tumorigenic properties remain unexplored. Using the ApcMin/+ mouse crosse... |
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Long-Term Mild, rather than Intense, Exercise Enhances Adult Hippocampal Neurogenesis and Greatly Changes the Transcriptomic Profile of the Hippocampus.
PLoS ONE 10 , e0128720, (2015) Our six-week treadmill running training (forced exercise) model has revealed that mild exercise (ME) with an intensity below the lactate threshold (LT) is sufficient to enhance spatial memory, while intense exercise (IE) above the LT negates such benefits. To... |