Amifostine trihydrate
Amifostine trihydrate structure
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Common Name | Amifostine trihydrate | ||
|---|---|---|---|---|
| CAS Number | 112901-68-5 | Molecular Weight | 268.269 | |
| Density | 1.367g/cm3 | Boiling Point | 441.7ºC at 760 mmHg | |
| Molecular Formula | C5H21N2O6PS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 220.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation.
In Vivo 26(6) , 889-97, (2012) Use of zebrafish models may decrease the cost of screening new irradiation protectors and mitigators.Zebrafish (Danio rerio) models were tested for screening water-soluble radiation protectors and mitigators. Irradiation of embryos and monitoring survival, an... |
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A Phase I Clinical and Pharmacology Study Using Amifostine as a Radioprotector in Dose-escalated Whole Liver Radiation Therapy
Int. J. Radiat. Oncol. Biol. Phys. 83(5) , 1441-7, (2012) Purpose Diffuse intrahepatic tumors are difficult to control. Whole-liver radiotherapy has been limited by toxicity, most notably radiation-induced liver disease. Amifostine is a prodrug free-radical scavenger that selectively protects normal tissues and, in ... |
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The effect of Amifostine (Ethyol) on intestinal anastomosis in rats with radiation enteritis.
Eur. Rev. Med. Pharmacol. Sci. 17(10) , 1351-9, (2013) Preoperative radiotherapy in colorectal cancers is being used as an adjuvant therapy with increasing frequency. Postoperative complications in early and late periods in various ratios are reported. It has also been shown that radiation has a delaying effect o... |
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High glucose inhibits the aspirin-induced activation of the nitric oxide/cGMP/cGMP-dependent protein kinase pathway and does not affect the aspirin-induced inhibition of thromboxane synthesis in human platelets.
Diabetes 61(11) , 2913-21, (2012) Since hyperglycemia is involved in the "aspirin resistance" occurring in diabetes, we aimed at evaluating whether high glucose interferes with the aspirin-induced inhibition of thromboxane synthesis and/or activation of the nitric oxide (NO)/cGMP/cGMP-depende... |
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Raman spectroscopy demonstrates Amifostine induced preservation of bone mineralization patterns in the irradiated murine mandible.
Bone 52(2) , 712-7, (2013) Adjuvant radiotherapy in the management of head and neck cancer remains severely debilitating. Fortunately, newly developed agents aimed at decreasing radiation-induced damage have shown great promise. Amifostine (AMF) is a compound, which confers radio-prote... |
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A new orally active, aminothiol radioprotector-free of nausea and hypotension side effects at its highest radioprotective doses.
Int. J. Radiat. Oncol. Biol. Phys. 82(5) , e701-7, (2012) A new aminothiol, PrC-210, was tested for orally conferred radioprotection (rats, mice; 9.0 Gy whole-body, which was otherwise lethal to 100% of the animals) and presence of the debilitating side effects (nausea/vomiting, hypotension/fainting) that restrict u... |
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Amifostine, a radioprotectant agent, protects rat brain tissue lipids against ionizing radiation induced damage: an FTIR microspectroscopic imaging study.
Arch. Biochem. Biophys. 520(2) , 67-73, (2012) Amifostine is the only approved radioprotective agent by FDA for reducing the damaging effects of radiation on healthy tissues. In this study, the protective effect of amifostine against the damaging effects of ionizing radiation on the white matter (WM) and ... |
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Mushroom beta glucan: potential candidate for post irradiation protection.
Mutat. Res. 751(2) , 109-15, (2013) The in vivo radioprotective effect of a beta-glucan (BG) isolated from the mushroom Ganoderma lucidum, against radiation (RT) induced damage was investigated taking mouse survival, hematology, liver GSH (Reduced glutathione), liver Malondialdehyde (MDA) and b... |
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Amifostine protects vascularity and improves union in a model of irradiated mandibular fracture healing.
Plast. Reconstr. Surg. 132(6) , 1542-9, (2013) Pathologic fractures of the mandible can be devastating to cancer patients and are due in large part to the pernicious effects of irradiation on bone vascularity. The authors' aim was to ascertain whether amifostine, a radioprotective drug, will preserve vasc... |
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Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells.
Int. J. Oncol. 41(3) , 1157-63, (2012) The p53 protein is a sequence-specific transcription factor controlling the expression of multiple genes and protecting cells from oncogenic transformation. In many tumors, the p53 protein is completely or partially inactivated by mutations in the p53 gene. W... |