DSS Crosslinker
DSS Crosslinker structure
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Common Name | DSS Crosslinker | ||
|---|---|---|---|---|
| CAS Number | 68528-80-3 | Molecular Weight | 368.339 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 513.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C16H20N2O8 | Melting Point | 169-170ºC | |
| MSDS | Chinese USA | Flash Point | 264.4±32.9 °C | |
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Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.
J. Virol. 89(6) , 3256-74, (2015) Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 plays an essential role in KSHV lytic infection by promoting viral gene expression at the posttranscriptional level. Using bioinformatic and biochemical approaches, we determined that ORF57 contains two str... |
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Proteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1-Pba2 chaperone.
Nat. Commun. 6 , 6123, (2015) The chaperones Ump1 and Pba1-Pba2 promote efficient biogenesis of 20S proteasome core particles from its subunits via 15S intermediates containing alpha and beta subunits, except beta7. Here we elucidate the structural role of these chaperones in late steps o... |
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Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.
Br. J. Pharmacol. 172(2) , 593-605, (2014) Naturally occurring single-nucleotide polymorphisms (SNPs) within GPCRs can result in alterations in various pharmacological parameters. Understanding the regulation and function of endocytic trafficking of the μ-opioid receptor (MOP receptor) is of great imp... |
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p32, a novel binding partner of Mcl-1, positively regulates mitochondrial Ca(2+) uptake and apoptosis.
Biochem. Biophys. Res. Commun. 451(2) , 322-8, (2014) Mcl-1 is a major anti-apoptotic Bcl-2 family protein. It is well known that Mcl-1 can interact with certain pro-apoptotic Bcl-2 family proteins in normal cells to neutralize their pro-apoptotic functions, thus prevent apoptosis. In addition, it was recently f... |
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Imidate-based cross-linkers for structural proteomics: increased charge of protein and peptide ions and CID and ECD fragmentation studies.
J. Am. Soc. Mass Spectrom. 25(7) , 1181-91, (2014) Chemical cross-linking is an attractive low-resolution technique for structural studies of protein complexes. Distance constraints obtained from cross-linked peptides identified by mass spectrometry (MS) are used to construct and validate protein models. Amid... |
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Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages.
J. Immunol. 194 , 5472-87, (2015) PGE2 is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation and cancer. Nucleotide-binding domain, leucine-rich repeat-containing protein (NLR)P3 inflammasome plays... |
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In vivo effect of immobilisation of bone morphogenic protein 2 on titanium implants through nano-anchored oligonucleotides.
Eur. Cell. Mater. 30 , 28-40; discussion 40, (2015) The aim of the present study was to test the hypothesis that immobilisation of bone morphogenic proteins on the surface of titanium implants through nano-anchored oligonucleotides can enhance peri-implant bone formation. Non-coding 60-mer DNA oligonucleotides... |
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Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling.
J. Biol. Chem. 290 , 20167-84, (2015) We recently described the induction of noncanonical IL-1β processing via caspase-8 recruited to ripoptosome signaling platforms in myeloid leukocytes. Here, we demonstrate that activated NLRP3·ASC inflammasomes recruit caspase-8 to drive IL-1β processing in m... |
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Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly.
Nat. Commun. 6 , 7387, (2015) In eukaryotes, RNA Polymerase III (Pol III) is specifically responsible for transcribing genes encoding tRNAs and other short non-coding RNAs. The recruitment of Pol III to tRNA-encoding genes requires the transcription factors (TF) IIIB and IIIC. TFIIIC has ... |
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A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
Nat. Commun. 6 , 7222, (2015) The neuregulin receptor ErbB4 is an important modulator of GABAergic interneurons and neural network synchronization. However, little is known about the endogenous ligands that engage ErbB4, the neural processes that activate them or their direct downstream t... |