Acetyl-L-tryptophan

Acetyl-L-tryptophan Structure
Acetyl-L-tryptophan structure
Common Name Acetyl-L-tryptophan
CAS Number 1218-34-4 Molecular Weight 246.262
Density 1.3±0.1 g/cm3 Boiling Point 586.6±45.0 °C at 760 mmHg
Molecular Formula C13H14N2O3 Melting Point 190ºC
MSDS Chinese USA Flash Point 308.6±28.7 °C

Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Nat. Chem. Biol. 5 , 45-52, (2009)

Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting transceptors is unknown. We have screened 319 amino acid anal...

Electron transfer from aromatic amino acids to triplet quinones.

J. Photochem. Photobiol. B, Biol. 88(2-3) , 83-9, (2007)

The photoreduction of 1,4-benzoquinone, 1,4-naphthoquinone, 9,10-anthraquinone (AQ) and several methylated or halogenated derivatives in argon-saturated acetonitrile-water mixtures by indole, N-acetyltryptophan and N-acetyltyrosine was studied by time-resolve...

Nucleoprotein photo-cross-linking using halopyrimidine-substituted RNAs.

Meth. Enzymol. 318 , 88-104, (2000)

Stabilizing mechanisms in commercial albumin preparations: octanoate and N-acetyl-L-tryptophanate protect human serum albumin against heat and oxidative stress.

Biochim. Biophys. Acta 1702 , 9-17, (2004)

The capability of octanoate, N-acetyl-L-tryptophanate (N-AcTrp) and other ions of fatty acids and amino acids to stabilize human serum albumin (HSA) against thermal and oxidative stress was studied. Native-PAGE showed that octanoate, and more hydrophobic fatt...

Pressure effects on tryptophan and its derivatives.

Biochem. Biophys. Res. Commun. 269(3) , 681-6, (2000)

The high pressure effects on fluorescence of free tryptophan (Trp) and its derivatives, N-acetyl-tryptophan (AT), N-acetyl-tryptophanamide (NATA), tryptophanamide (TA), and tryptophan, containing 6-polypeptides in aqueous solution, were investigated in a pres...

Substance P-induced changes in cell genesis following diffuse traumatic brain injury.

Neuroscience 214 , 78-83, (2012)

Inhibition of substance P (SP) activity through the use of NK1 receptor antagonists has been shown to be a promising neuroprotective therapy following traumatic brain injury (TBI). Conversely, recent research has implicated SP in the stimulation of neurogenes...

Ultrafast dynamics of nonequilibrium electron transfer in photoinduced redox cycle: solvent mediation and conformation flexibility.

J. Phys. Chem. B 116(30) , 9130-40, (2012)

We report here our systematic characterization of a photoinduced electron-transfer (ET) redox cycle in a covalently linked donor-spacer-acceptor flexible system, consisting of N-acetyl-tryptophan methylester as an electron donor and thymine as an electron acc...

Electron transfer between guanosine radicals and amino acids in aqueous solution. II. Reduction of guanosine radicals by tryptophan.

J. Phys. Chem. B 112(9) , 2747-54, (2008)

The efficiency of the chemical pathway of DNA repair is studied by time-resolved chemically induced dynamic nuclear polarization (CIDNP) using the model system containing guanosyl base radicals, and tryptophan as the electron donor. Radicals were generated ph...

Degradation of N-acetyl tryptophan by low-energy (<12 eV) electrons.

J. Am. Chem. Soc. 126(38) , 12158-61, (2004)

Secondary low-energy electrons are abundantly created during the early moments following the deposition of energy by radiation into cells. Here we show the ability of slow (<12 eV) electrons to effectively decompose gas-phase N-acetyl tryptophan (NAT) which c...

Industrial stabilizers caprylate and N-acetyltryptophanate reduce the efficacy of albumin in liver patients.

Liver Transpl. 17(6) , 705-9, (2011)

Liver failure is associated with an accumulation of toxic molecules that exert an affinity to albumin. Some of them have vasoactive activity. So far, albumin has been used as a plasma expander to improve the available circulating blood volume. However, recent...